CAREER: Amyloid fibril formation in bulk solution and on supported phospholipid bilayers

职业：在本体溶液中和支持的磷脂双层上形成淀粉样原纤维

• 批准号: 0644826
• 负责人: Melissa Moss
• 金额: $ 40万
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0644826&HistoricalAwards=false
• 关键词: CAREER; Amyloid; fibril; formation; bulk

0644826 Moss The project will explain the mechanism of amyloid fibril aggregation. Three aims are proposed: 1) screen compound libraries for inhibitors to amyloid fibril aggregation; 2) use the effective inhibitors to probe the aggregation processes in bulk solution and 3) on phospholipid surface. This work will involve a series of biochemical and biophysical analytical tools. The education program consists of a number of components: a caregiver shadowing program, providing lab research opportunities for undergraduate students, developing biomedical engineering courses, and mentoring minority and women students.The project will focus on the amyloid-beta protein which is a primary component of plaques found in Alzheimer's patients. This research will likely advance the knowledge of protein aggregation and potentially give rise to more effective treatments for Alzheimer's disease.

0644826 MOSS该项目将解释淀粉样原纤维聚集的机制。提出了三个目标：1)筛选淀粉样蛋白纤维聚集抑制剂的化合物文库；2)利用有效的抑制剂探索淀粉样蛋白纤维在溶液中的聚集过程；3)在磷脂表面上的聚集过程。这项工作将涉及一系列生化和生物物理分析工具。该教育计划由多个部分组成：照顾者跟踪计划，为本科生提供实验室研究机会，开发生物医学工程课程，以及指导少数族裔和女性学生。该项目将专注于淀粉样β蛋白，这是阿尔茨海默氏症患者斑块的主要成分。这项研究可能会促进蛋白质聚集的知识，并有可能产生更有效的阿尔茨海默病治疗方法。