CAREER: Amyloid fibril formation in bulk solution and on supported phospholipid bilayers

0644826莫斯该项目将解释淀粉样纤维聚集的机制。提出了三个目标：1）筛选化合物库中抑制淀粉样蛋白纤维聚集的抑制剂; 2）使用有效的抑制剂来探测本体溶液中的聚集过程; 3）在磷脂表面上。这项工作将涉及一系列生物化学和生物物理分析工具。该教育计划包括一些组成部分：照顾者跟踪计划，为本科生提供实验室研究机会，开发生物医学工程课程，并指导少数民族和女性学生。该项目将重点关注淀粉样β蛋白，这是阿尔茨海默氏症患者斑块的主要成分。这项研究可能会推进蛋白质聚集的知识，并可能产生更有效的治疗阿尔茨海默病的方法。

0644826 Moss The project will explain the mechanism of amyloid fibril aggregation. Three aims are proposed: 1) screen compound libraries for inhibitors to amyloid fibril aggregation; 2) use the effective inhibitors to probe the aggregation processes in bulk solution and 3) on phospholipid surface. This work will involve a series of biochemical and biophysical analytical tools. The education program consists of a number of components: a caregiver shadowing program, providing lab research opportunities for undergraduate students, developing biomedical engineering courses, and mentoring minority and women students.The project will focus on the amyloid-beta protein which is a primary component of plaques found in Alzheimer's patients. This research will likely advance the knowledge of protein aggregation and potentially give rise to more effective treatments for Alzheimer's disease.