CAREER: Structure-Property Relationships for Mixed Ligand 'Rippled' Nanoparticles and their Polymer-like Assemblies

职业：混合配体“波纹”纳米颗粒及其类聚合物组件的结构-性能关系

• 批准号: 0645323
• 负责人: Francesco Stellacci
• 金额: $ 50万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645323&HistoricalAwards=false
• 关键词: CAREER; Structure; Property; Relationships; Mixed

Technical AbstractLigand coated nanoparticles are assemblies consisting of an inorganic core protected by a self-assembled monolayer, often composed of a mixture of different molecules that together determine a large fraction of the particles' properties. Recently, using scanning tunneling microscopy, the presence of concentric ribbon-like domains of alternating composition when the ligand shell of gold nanoparticles is composed of phase-separated mixture of thiolated molecules has been shown. Significant properties, such as solubility or resistance to protein nonspecific adsorption, were found to depend on this arrangement. A series of studies to construct a set of ripple-structure/nanoparticle-property relationships are proposed. The goal is to contribute to the understanding of the interactions that happen between bio-molecules, such as viruses or protein globules, that also show nanometer scale domains on their outside 'shell'. Furthermore, we propose to create chains of 'divalent' nanoparticles to find the similarities and the differences that these nanoscale equivalents to polymers have with their molecular counterparts. The proposed work will naturally be integrated with undergraduate education efforts, for example by creating an open web version of his "Nanoscale Materials" class, and by creating two new laboratory experiments in the "Materials Laboratory" class.Non-Technical AbstractCells are molecular assemblies kept in nanometer-scale spatial arrangements by supramolecular interactions. Also, biomolecules, such as viruses or protein globules, have nanometer-scale assemblies of molecules on their outside. Recently, it has been observed that a synthetic material (ligand coated metal nanoparticles) shows a supramolecular arrangement on its outside shell that resembles, in size and composition, that present on biomolecules. It is proposed that these similarities be studied to try to understand what properties these types of arrangements determine. The goal is to contribute to the understanding of the interactions that biomolecules have among themselves and with the outside molecular world. The proposed work will be undertaken with the simultaneous training of a graduate student and many undergraduate students. In particular every year two summer undergraduate students will be hired from a local community college (Roxbury Community College) in order to expose young students from underrepresented minorities to the vibrant research environment at MIT. The proposed work will be an integral part of the P.I.'s undergraduate education efforts, for example by creating an open web version of the "Nanoscale Materials" class as well as two new laboratory experiments in the "Materials Laboratory" class.

技术摘要配体包覆纳米粒子是由无机核心组成的组合，由自组装的单层保护，通常由不同分子的混合物组成，这些分子共同决定了粒子的很大一部分性质。近年来，利用扫描隧道显微镜研究发现，当金纳米粒子的配体壳由相分离的硫代分子混合物组成时，存在交替组成的同心带状结构域。重要的性质，如溶解度或抵抗蛋白质非特异性吸附，被发现依赖于这种排列。提出了一系列构建波纹结构/纳米颗粒-性能关系的研究。目标是有助于理解生物分子之间发生的相互作用，例如病毒或蛋白质球，它们也在其外部“外壳”上显示纳米级结构域。此外，我们建议创建“二价”纳米颗粒链，以发现这些纳米级聚合物等价物与其分子对应物的相似之处和差异。他提出的工作自然会与本科教育相结合，例如创建一个开放的网络版本的“纳米材料”课程，并在“材料实验室”课程中创建两个新的实验室实验。细胞是通过超分子相互作用保持在纳米尺度空间排列的分子集合。此外，生物分子，如病毒或蛋白质球，在其外部有纳米级的分子组装。最近，人们观察到一种合成材料（配体包覆的金属纳米颗粒）在其外壳上显示出一种超分子排列，其大小和组成类似于生物分子。有人建议对这些相似性进行研究，以试图理解这些类型的排列决定了什么性质。目标是有助于理解生物分子之间以及与外部分子世界的相互作用。拟议的工作将在同时训练一名研究生和许多本科生的情况下进行。特别是每年将从当地社区学院（罗克斯伯里社区学院）聘请两名暑期本科生，以便让来自少数族裔的年轻学生接触到麻省理工学院充满活力的研究环境。建议的工作将是私人调查处的一个组成部分例如，通过创建“纳米材料”课程的开放网络版本，以及在“材料实验室”课程中开设两个新的实验室实验。