PFI: Creating Value from Agricultural Materials for the Biomedical Market

创新伙伴关系项目“为生物医学市场创造农业材料的价值”提出了一个为期两年的多阶段计划，以开发和评估一类新的可降解生物材料，这些材料来自丰富的植物多糖淀粉。 合作伙伴，新泽西生物材料中心（NJCBM），一个正式的学术财团与工业合作，将创建混合嵌段共聚物使用收敛组装合成技术，其中预功能化的生物聚合物和合成聚合物构建块以适当的比例组合，以得到目标二嵌段或三嵌段共聚物。 生物聚合物结构单元将由天然淀粉通过首先利用生物化学改性来改变多糖的分子量和聚合物结构，然后化学官能化生物聚合物的还原端以引入反应性末端官能度来产生。 合成聚合物结构单元将通过合适的单体与官能引发剂的直接聚合或预形成的聚酯的末端的化学改性来产生。 该研究计划将创建一个新的可降解生物材料平台，并对这些材料如何在表面和生物界面发挥作用以及自组装成纳米结构进行科学理解。 由于新材料基于淀粉生物聚合物和聚酯，因此与现有嵌段聚合物技术相比，它们将是可降解的，具有良好的功能特性，具有广泛的定制设计范围，并提供更高的成本效益。 将创建一个战略专利组合，其中包括新的物质成分以及这些材料在生物医学、食品包装和个人护理领域的应用。 这项知识产权将为未来的许可和技术转让活动提供基础，远远超出了拟议的两年期项目。通过合作伙伴关系开发的科学和技术（材料和用途）将把廉价和可再生的植物多糖带入高价值的生物医学，食品包装和个人护理最终用途领域。 这些植物多糖将为美国农业带来明显的经济效益。 该研究有望为基于植物多糖的生物材料与人体组织的相互作用提供基础知识。 生命科学和生物工程研究将受益于有一类新的材料可用于组织工程和药物输送系统。合作伙伴：合作伙伴包括罗格斯州立大学的新泽西，新玩法（牵头机构），罗格斯库克学院（中心先进食品技术（CAFT）），美国农业部-农业研究服务（USDA-ARS）和萨尔瓦多有限责任公司。

The Partnerships for Innovation project, Creating Value from Agricultural Materials for the Biomedical Market , proposes a two-year multiphase program to develop and evaluate a new class of degradable biomaterials derived from the abundant plant polysaccharide starch. The partners, the New Jersey Center for Biomaterials (NJCBM),a formal academic consortium working with industry, will create hybrid block copolymers using a convergent assembly synthesis technique where pre-functionalized biopolymer and synthetic polymer building blocks are combined in the appropriate ratios to give the target diblock or triblock copolymers. The biopolymer building blocks will be created from native starch by first utilizing biochemical modifications to alter the molecular weight and polymer architecture of the polysaccharide and then chemically functionalizing the reducing end of the biopolymer to introduce reactive terminal functionality. The synthetic polymer building blocks will be created either by direct polymerization of suitable monomer with functional initiators or chemical modification of the terminals of pre-formed polyesters. The research program will create a new degradable biomaterials platform, and develop scientific understanding of how these materials function at surfaces and biological interfaces, and self-assemble into nanostructures. Because the new materials are based on starch biopolymer and polyester, they will be degradable, have good functional characteristics, exhibit a broad custom design scope and provide improved cost-effectiveness compared to existing block polymer technology. A strategic patent portfolio will be created that includes the new compositions of matter and the use of these materials in biomedical, food packaging, and personal care areas. This intellectual property will provide the basis for future licensing and technology transfer activities well beyond the proposed two-year project.The science and technology (materials and use) developed through the partnership will bring inexpensive and renewable plant polysaccharides into high value biomedical, food packaging, and personal care end use areas. These plant polysaccharides will have clear economic benefits for U.S. agriculture. The research is expected to provide fundamental knowledge relating to the interaction of biomaterials based on plant polysaccharide with human tissue. Life sciences and bioengineering research will benefit by having a new class of materials available for tissue engineering and drug delivery systems.Partners: Partners include Rutgers the State University of New Jersey, New Brunswick (Lead Institution); Rutgers Cook College (Center for Advanced Food Technology (CAFT); U.S. Department of Agriculture - Agriculture Research Service (USDA-ARS); and Salvona LLC.