PFI: Creating Value from Agricultural Materials for the Biomedical Market

创新伙伴关系项目，为生物医学市场创造农业材料的价值，提出了一个为期两年的多阶段计划，以开发和评估一种从丰富的植物多糖淀粉中提取的新型可降解生物材料。合作伙伴新泽西生物材料中心(NJCBM)是一个与工业界合作的正式学术联盟，它将使用聚合组装合成技术创造混合嵌段共聚物，这种技术将预先功能化的生物聚合物和合成聚合物构建块以适当的比例结合在一起，得到目标二嵌段或三嵌段共聚物。生物聚合物构建块将从天然淀粉中创建，首先利用生化修饰来改变多糖的分子量和聚合物结构，然后对生物聚合物的还原末端进行化学官能化，以引入活性末端功能。合成聚合物构建块将通过适当的单体与官能化引发剂直接聚合或对预制聚酯的末端进行化学修饰来创建。该研究计划将创建一个新的可降解生物材料平台，并对这些材料如何在表面和生物界面上发挥作用，以及如何自组装成纳米结构进行科学理解。由于新材料是基于淀粉生物聚合物和聚酯的，它们将是可降解的，具有良好的功能特性，显示出广泛的定制设计范围，并与现有的嵌段聚合物技术相比提供更高的成本效益。将创建一个战略专利组合，其中包括物质的新组成以及这些材料在生物医学、食品包装和个人护理领域的使用。这一知识产权将为未来的许可和技术转让活动提供基础，远远超出拟议的两年项目。通过合作伙伴关系开发的科学和技术(材料和用途)将把廉价和可再生的植物多糖带入高价值的生物医学、食品包装和个人护理最终用途领域。这些植物多糖将为美国农业带来明显的经济效益。这项研究有望提供以植物多糖为基础的生物材料与人体组织相互作用的基础知识。生命科学和生物工程研究将受益于可用于组织工程和药物输送系统的新型材料。合作伙伴：合作伙伴包括罗格斯大学、新泽西州立大学、新不伦瑞克州立大学(牵头机构)、罗格斯大学库克学院(高级食品技术中心)、美国农业部-农业研究服务局(USDA-ARS)和萨尔瓦多有限责任公司。

The Partnerships for Innovation project, Creating Value from Agricultural Materials for the Biomedical Market , proposes a two-year multiphase program to develop and evaluate a new class of degradable biomaterials derived from the abundant plant polysaccharide starch. The partners, the New Jersey Center for Biomaterials (NJCBM),a formal academic consortium working with industry, will create hybrid block copolymers using a convergent assembly synthesis technique where pre-functionalized biopolymer and synthetic polymer building blocks are combined in the appropriate ratios to give the target diblock or triblock copolymers. The biopolymer building blocks will be created from native starch by first utilizing biochemical modifications to alter the molecular weight and polymer architecture of the polysaccharide and then chemically functionalizing the reducing end of the biopolymer to introduce reactive terminal functionality. The synthetic polymer building blocks will be created either by direct polymerization of suitable monomer with functional initiators or chemical modification of the terminals of pre-formed polyesters. The research program will create a new degradable biomaterials platform, and develop scientific understanding of how these materials function at surfaces and biological interfaces, and self-assemble into nanostructures. Because the new materials are based on starch biopolymer and polyester, they will be degradable, have good functional characteristics, exhibit a broad custom design scope and provide improved cost-effectiveness compared to existing block polymer technology. A strategic patent portfolio will be created that includes the new compositions of matter and the use of these materials in biomedical, food packaging, and personal care areas. This intellectual property will provide the basis for future licensing and technology transfer activities well beyond the proposed two-year project.The science and technology (materials and use) developed through the partnership will bring inexpensive and renewable plant polysaccharides into high value biomedical, food packaging, and personal care end use areas. These plant polysaccharides will have clear economic benefits for U.S. agriculture. The research is expected to provide fundamental knowledge relating to the interaction of biomaterials based on plant polysaccharide with human tissue. Life sciences and bioengineering research will benefit by having a new class of materials available for tissue engineering and drug delivery systems.Partners: Partners include Rutgers the State University of New Jersey, New Brunswick (Lead Institution); Rutgers Cook College (Center for Advanced Food Technology (CAFT); U.S. Department of Agriculture - Agriculture Research Service (USDA-ARS); and Salvona LLC.