Linear and Non-Linear Optical Activity Studies

线性和非线性光学活性研究

• 批准号: 0650524
• 负责人: Robert Compton
• 金额: $ 30万
• 依托单位: University of Tennessee Knoxville
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0650524&HistoricalAwards=false
• 关键词: Linear; Non; Optical; Activity; Studies

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Robert N. Compton of the University of Tennessee-Knoxville. This research will involve the study of chiral molecules (molecules with a non-superimposable mirror image) using novel laser based optical spectroscopy. The study will involve high-power lasers which allow for "multiple-photon" absorption by chiral molecules, called non-linear multiphoton spectroscopy, as opposed to the one-photon (linear spectroscopy) used for many, many years. The study of these multiphoton chiro-optical processes will allow greater understanding of chiral molecules. Further, attempts will be made to do asymmetric synthesis, that is, the preparation of a single optical isomer, using multiphoton excitation with circularly polarized light. Circularly polarized light (of which there is left and right circularly polarized light) interacts differently with the two non-superimposable mirror image molecules. Thus it may be possible to have the circularly polarized light produce a product which is one of the two mirror images. The experimental work will be supported by theoretical calculations.In terms of the broader impacts, this research will impact the synthesis of chiral organic molecules. Many organic molecules such as drugs and the molecules of living creatures are chiral and there is tremendous interest in synthesizing chiral molecules, which is not an easy thing to do well. This research will also touch on the subject of the origins of life by addressing the question "why are all amino acids or sugars in life molecules of one handedness?" This research is also an excellent vehicle for training both chemistry and physics students, since this research spans both disciplines, and to broaden the knowledge and training of both.

有了这个奖项，有机和高分子化学计划支持教授罗伯特N。田纳西-诺克斯维尔大学的康普顿。 这项研究将涉及手性分子（具有不可重叠镜像的分子）的研究，使用新型激光光谱。 这项研究将涉及高功率激光器，它允许手性分子的“多光子”吸收，称为非线性多光子光谱学，而不是多年来使用的单光子（线性光谱学）。 这些多光子手性光学过程的研究将使更多的了解手性分子。 此外，将尝试进行不对称合成，即，使用圆偏振光的多光子激发制备单一光学异构体。 圆偏振光（其中有左圆偏振光和右圆偏振光）与两个不可重叠的镜像分子以不同的方式相互作用。 因此，可以使圆偏振光产生作为两个镜像之一的产物。 实验工作将得到理论计算的支持，就更广泛的影响而言，本研究将对手性有机分子的合成产生影响。 许多有机分子如药物和生物分子都是手性的，因此合成手性分子具有巨大的兴趣，但这并不是一件容易的事情。 这项研究还将通过解决“为什么生命分子中所有的氨基酸或糖都是单手的”这个问题来触及生命起源的主题。“这项研究也是培训化学和物理学生的一个很好的工具，因为这项研究跨越了两个学科，并扩大了两者的知识和培训。