Transient Surface Temperature Response as Diagnostic Tool in Medicine and Engineering Applications

0651981作为诊断工具的瞬时表面温度响应在医学和工程应用中的应用分层系统的表面温度，如蒙皮，在外部加热或冷却时，根据地下结构的性质和布置以及施加的热边界条件而变化。生物系统通常具有与新陈代谢活动和血液流动相关的空间分布的内部热源。该项目的目标是调查地表温度对冷却或加热的瞬时响应，以确定地下结构和工艺。研究人员先前的研究表明，在有实际意义的情况下(皮肤癌，如黑色素瘤)，可以建立瞬时表面温度特征与表面下结构(癌症病变)的大小、形状和位置之间的相关性。为了将瞬变表面温度特征与地下结构联系起来，人们正在建立精确的数学模型，并进行实验验证。其目的是开发相对便宜、非侵入性、快速的测量和诊断工具，该工具基于瞬时红外表面温度测量并使用数值模型进行解释，用于识别实际感兴趣的亚表面结构(例如，黑色素瘤的诊断、复合材料结构中的故障检测等)。这项研究将导致开发出更好的健康和癌症组织模型，以及它们对热刺激的反应。癌症是美国第二大死因。目前，黑色素瘤是美国增长最快的恶性肿瘤，一生的风险为68分之一，生存的关键仍然是早期发现和手术切除。到目前为止，还没有开发出有效的筛查工具来提高这种疾病的早期诊断，诊断标准仍然是主观的。对于包括恶性黑色素瘤在内的危及生命的疾病，存在一种相对简单、非侵入性和廉价的诊断工具，如本项目要研究的工具，将对受这些疾病影响的人产生广泛的影响。这项拟议的研究有望在不进行活组织检查的情况下识别癌症(而不是良性生长)。

0651981 TRANSIENT SURFACE TEMPERATURE RESPONSE AS DIAGNOSTIC TOOL INMEDICINE AND ENGINEERING APPLICATIONSThe surface temperatures of layered systems, such as skin, vary under external heating or cooling depending on the properties and arrangement of subsurface structures and the imposed thermal boundary conditions. Biological systems typically have spatially distributed internal heat sources linked to metabolic activity and blood flow. The goal of the project is to investigate the transient surface temperature response to cooling or heating in order to identify subsurface structures and processes. Prior studies by the investigators suggest that, in cases of practical significance (skin cancers such as melanoma) a correlation between the transient surface temperature signature and the size, shape and location of the subsurface structures (cancerous lesions) can be established. In order to relate transient surface temperature signature to subsurface structures, accurate mathematical models are being developed and verified experimentally. The objective is to develop relatively inexpensive, non-invasive, rapid measurement and diagnostic tools, based on transient infrared surface temperature measurements and interpreted using numerical modeling, for the identification of subsurface structures of practical interest (for example, the diagnosis of melanoma, detection of failure in composite structures, etc.). The research will lead to the development of better models of healthy and cancerous tissues and their response to thermal excitation. Cancer is the second leading cause of death in the United States. Currently, melanoma is the fastest growing malignancy in the US with the lifetime risk being 1 in 68 and the key to survival remains early detection and surgical excision. To date, no effective screening tools have been developed to enhance the early diagnosis of this disease and the criteria for diagnosis remain subjective. The existence of a relatively simple, non-invasive and inexpensive diagnostic tool, such as the one to be investigated in this project, for conditions that are life threatening, including malignant melanoma, would have a wide-ranging impact on people affected by these conditions. The proposed research holds the promise of allowing the identification of cancerous (as opposed to benign growth) without biopsy.