Development of Biomaterial Microstructure and Surface Chemistry for Tissue Engineering of Intestine

Rebecca Carrier0700764本研究致力于利用组织工程技术开发一种用于重建肠上皮的微机械衬底。它涉及到使用微机械加工技术来制造模仿肠道独特空间地形的支架。如果成功，重组的上皮细胞将有巨大的潜力作为加快药物开发的工具，作为研究药物转运的体外培养系统。这项工作的完成将加强对肠道组织和运输的了解。此外，还将为可以商业化的产品奠定基础，用于快速药物开发或筛选技术。

Rebecca Carrier0700764This research focuses on the development of a micromachined substrate for the reconstitution of an intestinal epithelium using tissue engineering technology. It involves the use of micromachining techniques to fabricate a scaffold that mimics the unique spatial topography of an intestine. If successful, the reconstituted epithelium will have great potential as a tool to expedite drug development as an in vitro culture system to investigate drug transport. Completion of the work will enhance understanding of intestinal tissue and transport. Also, the foundation will be built for products that can be commercialized for rapid drug development or screening techniques.