Development of Biomaterial Microstructure and Surface Chemistry for Tissue Engineering of Intestine

肠道组织工程生物材料微观结构和表面化学的发展

• 批准号: 0700764
• 负责人: Rebecca Carrier
• 金额: --
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0700764&HistoricalAwards=false
• 关键词: Development; Biomaterial; Microstructure; Surface; Chemistry

Rebecca Carrier0700764This research focuses on the development of a micromachined substrate for the reconstitution of an intestinal epithelium using tissue engineering technology. It involves the use of micromachining techniques to fabricate a scaffold that mimics the unique spatial topography of an intestine. If successful, the reconstituted epithelium will have great potential as a tool to expedite drug development as an in vitro culture system to investigate drug transport. Completion of the work will enhance understanding of intestinal tissue and transport. Also, the foundation will be built for products that can be commercialized for rapid drug development or screening techniques.

Rebecca Carrier0700764这项研究的重点是开发一种微机械基底，用于利用组织工程技术重建肠上皮。 它涉及使用微加工技术来制造模仿肠道独特空间地形的支架。如果成功，重建的上皮将具有作为加速药物开发的工具的巨大潜力，作为研究药物转运的体外培养系统。 这项工作的完成将增强对肠道组织和运输的了解。 此外，还将为可商业化的产品建立基础，以用于快速药物开发或筛选技术。