Development of Biomaterial Microstructure and Surface Chemistry for Tissue Engineering of Intestine

本研究的重点是利用组织工程技术开发用于肠上皮重建的微机械基质。它包括使用微机械加工技术来制造一个模仿肠道独特空间地形的支架。如果成功，重建的上皮将有很大的潜力，作为一种工具，加快药物开发作为体外培养系统来研究药物转运。这项工作的完成将加深对肠道组织和运输的理解。此外，该基金还将为可用于快速药物开发或筛选技术的商业化产品建立基础。

Rebecca Carrier0700764This research focuses on the development of a micromachined substrate for the reconstitution of an intestinal epithelium using tissue engineering technology. It involves the use of micromachining techniques to fabricate a scaffold that mimics the unique spatial topography of an intestine. If successful, the reconstituted epithelium will have great potential as a tool to expedite drug development as an in vitro culture system to investigate drug transport. Completion of the work will enhance understanding of intestinal tissue and transport. Also, the foundation will be built for products that can be commercialized for rapid drug development or screening techniques.