Regenerative biomaterial patches for failing hearts

用于衰竭心脏的再生生物材料贴片

• 批准号: MR/X024210/1
• 负责人: Adam Celiz
• 金额: $ 75.73万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX024210%2F1
• 关键词: Regenerative; biomaterial; patches; failing; hearts

Regenerative medicine has been established as a powerful approach to repair and restore tissue function and has facilitated the development of a new era of medical procedures and healthcare technologies. However, many of these technologies have failed to reach the clinic due to poor methods of therapeutic delivery which fails to effectively target the tissues intended for repair.To improve clinical outcomes, biomaterials have been developed with the aim to control drug and cell delivery in sustained and localised manner. However, biomaterials currently under investigation are not able to adhere to target tissues and rely on sutures to hold them in place which induces further tissue damage and inflammation. Furthermore, a mechanical demanding environment such as beating heart requires the biomaterial to be robust and able to conform to the dynamic nature of the tissue. For example, myocardial infarction can lead to the death of 1 billion cardiomyoctes and cell-delivery to infarcted hearts is an emerging therapy to heal the diseased cardiac tissue. However, the efficacy of these treatments has been limited due to the lack of advanced cell-delivery methods.The overall goal of this research is to improve clinical outcomes associated with regenerative therapies by using adhesive biomaterials as drug delivery vehicles. The specific biomaterials that will be developed to deliver drugs are hydrogels which are high-water content swollen gels. Hydrogels are a highly desirable class of materials to encapsulate cells and drugs as they can be synthesised to mimic natural tissues which increases the biocompatibility of these systems. The hydrogels developed in this research are highly stretchable, so they can be deployed in physical demanding environments, and tissue adhesive which allows the encapsulated drugs to closely interface with the tissue surface and be delivered more efficiently.The outcomes of this research would open up new opportunities for regenerative medicine as these hydrogels could significantly increase the efficiency of cell and drug-based therapies, improve our treatment methods and understanding of diseased tissues and introduce innovative adhesive biomaterials to the clinic as regenerative medical devices.

再生医学已被确立为修复和恢复组织功能的一种强有力的方法，并促进了医疗程序和医疗保健技术新时代的发展。然而，由于治疗递送方法不佳，无法有效靶向需要修复的组织，许多这些技术未能进入临床。为了改善临床结果，生物材料已经被开发出来，目的是控制药物和细胞以持续和局部的方式传递。然而，目前正在研究的生物材料不能附着在目标组织上，依靠缝合线将它们固定在适当的位置，这会导致进一步的组织损伤和炎症。此外，机械要求苛刻的环境，如跳动的心脏，要求生物材料是坚固的，能够符合组织的动态性质。例如，心肌梗死可导致10亿心肌细胞死亡，将细胞输送到梗死心脏是一种新兴的治疗患病心脏组织的方法。然而，由于缺乏先进的细胞递送方法，这些治疗的效果受到限制。本研究的总体目标是通过使用黏附生物材料作为药物递送载体来改善与再生疗法相关的临床结果。将被开发用于递送药物的特定生物材料是水凝胶，它是一种高含水量的肿胀凝胶。水凝胶是一种非常理想的包裹细胞和药物的材料，因为它们可以合成成模拟自然组织，从而增加这些系统的生物相容性。本研究开发的水凝胶具有高度可拉伸性，因此可以在物理要求苛刻的环境中部署，并且具有组织粘合剂，可以使封装的药物与组织表面紧密结合并更有效地递送。这项研究的结果将为再生医学开辟新的机会，因为这些水凝胶可以显著提高细胞和药物治疗的效率，改进我们的治疗方法和对病变组织的理解，并将创新的粘附生物材料作为再生医疗设备引入临床。