Modeling, Analysis and Simulation of Surface Acoustic Wave Driven Microfluidic Biochips

本计画系关于声表面波驱动微流控生物晶片之数学建模、数值模拟与模型验证。这种生物芯片的操作行为代表了一个多物理场、多尺度问题，可以通过压电方程和可压缩Navier-Stokes方程的耦合来描述，该耦合的特征在于在极其不同的时间尺度上的流动模式。 将应用非均质化技术对产生的流场（声流）进行适当建模，并开发、分析和实施用于数值模拟的高效可靠的算法工具。生物芯片和生物阵列是用于制药、医学和法医学领域的DNA和蛋白质化学分析的设备，在基因组学、蛋白质组学和细胞分析中发挥着重要作用。当前的技术努力集中在保证显著加快分析速度的设备的开发上。微流体生物芯片的特征在于将流体集成在芯片本身上，并且可以提供这样的加速沿着，同时具有更好的灵敏度、灵活性和成本效益。该项目将导致更好地了解操作行为，并开发可用于生物芯片和生物阵列的优化设计的方法。

This project is concerned with the mathematical modeling, numerical simulation and model validation of surface-acoustic-wave driven microfluidic biochips. The operational behavior of such biochips represents a multiphysics, multiscale problem that can be described by a coupling of the equations of piezoelectrics and the compressible Navier-Stokes equations featuring flow patterns on extremely different time-scales. Heterogeneous homogenization techniques will be applied for a proper modeling of the resulting flow field (acoustic streaming) and develop, analyze and implement efficient and reliable algorithmic tools for the numerical simulation. A model validation will be performed on the basis of available experimental data.Biochips and bioarrays are devices that are used in pharmaceutical, medical and forensic applications for the chemical analysis of DNA and proteins and thus play an important role in genomics, proteomics, and cell analysis. Current technological efforts focus on the development of devices that guarantee a significant speed-up of the analysis. Microfluidic biochips are characterized by an integration of the fluidics on the chip itself and can provide such a speed-up along with a better sensitivity, flexibility, and cost-effectiveness. This project will lead to a better understanding of the operational behavior and develop methods that can be used for an optimal design of biochips and bioarrays.