NIRT: Active Nanophotofluidic Systems for Single Molecule/Particle Analysis

NIRT：用于单分子/颗粒分析的活性纳米光流控系统

• 批准号: 0708599
• 负责人: David Erickson
• 金额: $ 100万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0708599&HistoricalAwards=false
• 关键词: NIRT; Active; Nanophotofluidic; Systems; Single

0708599Erickson, David C.This NSF-NIRT award is centered around the active integration of nanophotonics, nanofluidics, nanomaterials and single molecule physics into a new field, refered herein as ''Nanophotofluidics''. The assembled team consists of researchers from Cornell University and the University of Rochester bringing distinct individual expertise to form the integrated, multidisciplinary research program to exploit the extremely high optical intensities achievable in our newly developed 50nm wide exposed mode ?slot waveguides? to perform optofluidic tweezing and propulsion (by exploiting polarization and scattering/adsorption forces) and demonstrate a series of new active nanoscopic single molecule and multi-particle analytical tools. Intellectual MeritThis program is divided into three focused research areas: 1) develop a better fundamental understanding of the coupling of electromagnetics and hydrodynamics on the nanoscale to demonstrate the core elements of a broader nanophotofluidic transport architecture, 2) demonstrate the most resolute separation mechanism developed to date, and 3) develop a new mechanism for investigating single protein folding dynamics in solution. Broader Impacts Integrating photonic elements as active components in micro- and nano-fluidic devices represents a largely unexplored area that could have significant impact that could be extended into a broad new class of photonically driven microfluidic devices where rapid, network based particle manipulation is performed using the high-speed components already developed by the telecommunications industry. Such platforms may find application in emerging fields such as nano-assembly (offering all the advantages of optical tweezing but more rapidly and with sub-wavelength precision). A fundamental part of this program is an outreach and education strategy consisting of: 1) The development of a series of integrated educational units distributed to K-12 classrooms nationwide through the Cornell Main Street Science program and 2) An interdisciplinary nanoscience and engineering seminar series for the upstate New York area. This seminar series will attract attendees from both universities as well as undergraduate institutions in upstate New York. The talks will also be posted on a dedicated website for download. Students from the target institutions will also be given the opportunity to post questions on a dedicated website which will be answered directly by the speaker or the PIs.This research is well aligned with both NSF Active Nanostructures and Nanoscale Devices and System Architecture research themes.

0708599Erickson，David C. 该 NSF-NIRT 奖项的重点是纳米光子学、纳米流体学、纳米材料和单分子物理学到新领域的积极整合，本文称为“纳米光流体学”。该团队由来自康奈尔大学和罗彻斯特大学的研究人员组成，他们带来了独特的个人专业知识，形成了综合的多学科研究计划，以利用我们新开发的 50nm 宽暴露模式“槽波导”可实现的极高光学强度。执行光流控镊子和推进（通过利用偏振和散射/吸附力）并演示一系列新的活性纳米级单分子和多粒子分析工具。智力优势该项目分为三个重点研究领域：1）对纳米尺度上电磁学和流体动力学的耦合有更好的基础理解，以展示更广泛的纳米光流体传输架构的核心要素，2）展示迄今为止开发的最坚决的分离机制，3）开发一种研究溶液中单一蛋白质折叠动力学的新机制。更广泛的影响将光子元件作为有源组件集成到微米和纳米流体设备中代表了一个很大程度上尚未探索的领域，该领域可能会产生重大影响，可以扩展到广泛的新型光子驱动微流体设备中，在这些设备中，使用电信行业已经开发的高速组件来执行基于网络的快速粒子操纵。 此类平台可能会在纳米组装等新兴领域得到应用（提供光镊的所有优点，但速度更快，并且具有亚波长精度）。 该计划的一个基本部分是外展和教育战略，包括：1）通过康奈尔大街科学计划开发一系列综合教育单元，分发到全国 K-12 教室；2）为纽约州北部地区举办跨学科纳米科学和工程研讨会系列。该研讨会系列将吸引来自纽约州北部大学和本科院校的与会者。会谈内容还将发布在专门网站上供下载。来自目标机构的学生还将有机会在专门的网站上发布问题，这些问题将由演讲者或 PI 直接回答。这项研究与 NSF 活性纳米结构和纳米级器件和系统架构研究主题非常一致。