I-Corps: High Efficiency Rapid Magnetic Erythrocyte Separator

这个I-Corps项目的更广泛影响/商业潜力是能够分散诊断血液检测。现有的护理点诊所局限于狭窄的诊断能力范围，因为它们目前不具备进行血浆分离的简单方法。高效快速磁性红细胞分离器（H.E.R.M.E.S）提供了一种高效的解决方案，以满足床旁环境中的样本处理需求，其商业化将使现有的诊断测试从传统实验室转化为更容易获得的临床环境。获得快速样本处理能力还将确保保持样本完整性，并减少可能因样本储存不良而导致的不准确诊断的发生率。此外，H.E.R.M.E.S非常适合集成到资源有限的医疗基础设施中，因为它可以提供低成本的样品处理能力。成功的部署将导致增加检测服务的可及性，并可能使护理点诊所获得更大比例的血液检测市场。H.E.R.M.E.S使用基于磁珠的分离，在短时间内获得不含红细胞的血浆。H.E.R.M.E.S是一个低成本的独立平台，有可能提高现有血液诊断检测的检测效率和转化能力。H.E.R.M.E.S将解决缺乏低成本和有效的样本处理技术的问题;这是阻止现有护理点诊所提供内部血液检测服务的障碍。目前的实验表明，H.E.R.M.E.S提供了与离心机相似的性能（接近100%血浆纯度），而时间和成本仅为离心机的一小部分（处理时间为2分钟，每次测试不到2美元）。基础研究补充了正在进行的工作，即开发即时医疗技术，以在现场进行诊断测试。该技术利用廉价的原材料，是现成的，和工艺流程的设计，以确保半自动操作？该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is to enable the decentralization of diagnostic blood testing. Existing point-of-care clinics are limited to a narrow range of diagnostic capabilities as they currently do not possess simple methods to perform blood-plasma separation. High Efficiency Rapid Magnetic Erythrocyte Separator (H.E.R.M.E.S) offers a highly efficient solution to meet the needs of sample processing in point-of-care environments and its commercialization will enable the translation of existing diagnostic tests from traditional labs to more accessible clinical settings. Access to rapid sample processing capabilities will also ensure retention of sample integrity and reduce the incidences of inaccurate diagnosis that may result from poor sample storage. Further, H.E.R.M.E.S is highly suitable to integrate into the healthcare infrastructure of resource-limited settings as it can provide low-cost sample processing capabilities. Successful deployment will result in an increased accessibility to testing services and will potentially allow point-of-care clinics to capture a greater percentage of the blood-testing marketThis I-Corps project explores the commercial potential of a translational method to perform blood-plasma separation. H.E.R.M.E.S uses magnetic bead-based separation to obtain plasma free of red blood cells in a short amount of time. H.E.R.M.E.S is a low-cost and standalone platform that has the potential to augment the testing efficiency and translational ability of existing blood-based diagnostic tests. H.E.R.M.E.S will address the lack of availability of low-cost and efficient sample processing technologies; a barrier that prevents existing point-of-care clinics from offering in-house blood testing services. Current experiments show that H.E.R.M.E.S offers performance similar to that of a centrifuge (near 100% plasma purity) at a fraction of the time and cost (process time of 2 minutes at less than $2 per test). The underlying research complements ongoing work in developing point-of-care medical technologies to perform diagnostic testing in the field. The technology utilizes inexpensive raw materials that are readily available, and the process flow has been designed to ensure semi-autonomous operation ? key factors that indicate favorable scale-up potential.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.