I-Corps: High Efficiency Rapid Magnetic Erythrocyte Separator

I-Corps：高效快速磁性红细胞分离器

• 批准号: 1837864
• 负责人: David Erickson
• 金额: $ 5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1837864&HistoricalAwards=false
• 关键词: Corps; Efficiency; Rapid; Magnetic; Erythrocyte

The broader impact/commercial potential of this I-Corps project is to enable the decentralization of diagnostic blood testing. Existing point-of-care clinics are limited to a narrow range of diagnostic capabilities as they currently do not possess simple methods to perform blood-plasma separation. High Efficiency Rapid Magnetic Erythrocyte Separator (H.E.R.M.E.S) offers a highly efficient solution to meet the needs of sample processing in point-of-care environments and its commercialization will enable the translation of existing diagnostic tests from traditional labs to more accessible clinical settings. Access to rapid sample processing capabilities will also ensure retention of sample integrity and reduce the incidences of inaccurate diagnosis that may result from poor sample storage. Further, H.E.R.M.E.S is highly suitable to integrate into the healthcare infrastructure of resource-limited settings as it can provide low-cost sample processing capabilities. Successful deployment will result in an increased accessibility to testing services and will potentially allow point-of-care clinics to capture a greater percentage of the blood-testing marketThis I-Corps project explores the commercial potential of a translational method to perform blood-plasma separation. H.E.R.M.E.S uses magnetic bead-based separation to obtain plasma free of red blood cells in a short amount of time. H.E.R.M.E.S is a low-cost and standalone platform that has the potential to augment the testing efficiency and translational ability of existing blood-based diagnostic tests. H.E.R.M.E.S will address the lack of availability of low-cost and efficient sample processing technologies; a barrier that prevents existing point-of-care clinics from offering in-house blood testing services. Current experiments show that H.E.R.M.E.S offers performance similar to that of a centrifuge (near 100% plasma purity) at a fraction of the time and cost (process time of 2 minutes at less than $2 per test). The underlying research complements ongoing work in developing point-of-care medical technologies to perform diagnostic testing in the field. The technology utilizes inexpensive raw materials that are readily available, and the process flow has been designed to ensure semi-autonomous operation ? key factors that indicate favorable scale-up potential.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

I-Corps项目的更广泛影响/商业潜力是使诊断血液检测能够分散。现有的定点诊所的诊断能力有限，因为它们目前没有进行血浆分离的简单方法。高效快速磁性红细胞分离器（H.E.R.M.E.S）提供了一种高效的解决方案，以满足在护理点环境中样品处理的需求，其商业化将使现有的诊断测试从传统实验室转化为更容易获得的临床环境。获得快速样品处理能力也将确保样品完整性的保留，并减少可能由于样品储存不良而导致的不准确诊断的发生率。此外，h.e.r.m.e.非常适合集成到资源有限的医疗保健基础设施中，因为它可以提供低成本的样本处理能力。成功部署将增加检测服务的可及性，并有可能使医疗点诊所获得更大比例的血液检测市场。I-Corps项目探索了一种进行血浆分离的转化方法的商业潜力。H.E.R.M.E.S使用基于磁珠的分离技术在短时间内获得不含红细胞的血浆。H.E.R.M.E.S是一种低成本的独立平台，有可能提高现有血液诊断测试的检测效率和转化能力。H.E.R.M.E.S将解决缺乏低成本和高效样品处理技术的问题；阻碍现有医疗点诊所提供内部血液检测服务的障碍。目前的实验表明，H.E.R.M.E.S的性能与离心机相似（接近100%的血浆纯度），而时间和成本都很低（每次测试的处理时间为2分钟，不到2美元）。基础研究补充了正在进行的开发护理点医疗技术的工作，以便在现场进行诊断测试。该技术使用了廉价的原材料，并且工艺流程的设计确保了半自主操作。显示有利的扩大潜力的关键因素。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。