NIRT: Exploiting Protein Cage Dynamics to Engineer Active Nanostructures

NIRT：利用蛋白质笼动力学设计活性纳米结构

• 批准号: 0709358
• 负责人: Trevor Douglas
• 金额: $ 100万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0709358&HistoricalAwards=false
• 关键词: NIRT; Exploiting; Protein; Cage; Dynamics

0709358DouglasThis proposal was received in response to the Active Nanostructures and Nanosystems initiative, NSF 06-595, category NIRT. Protein cage dynamics plays an important role in the overall properties of the nanomaterials. This NIRT project will develop structured nanomaterials by using engineered protein cage architectures. The research activities are integrated in three components: active interfaces, cage dynamics, and confinement. The central focus of this NIRT project is to determine how particle confinement and protein cage dynamics at active interfaces controls nanomaterials synthesis and material functionality. The research on development of protein cage architectures for nanomaterials synthesis will clarify fundamental design principles for future directed applications in microelectronics, catalysis, sensing, and medicine. The investigators will identify Native American students from Montana through MSU''s Undergraduate Scholars Program and involve them in the project. The researchers plan to collaborate with students in MSU''s Science and Natural History Filmaking program to produce two films on their research with protein cages.The long-term goal is to use the knowledge gained to guide the development of a new generation of active and responsive nanomaterials. Specifically the research on development of protein cage architectures for nanomaterials synthesis will reveal fundamental design principles for future directed applications in microelectronics, catalysis, sensing, and medicine.

0709358Douglas此提案是为了响应活性纳米结构和纳米系统倡议、NSF 06-595、NIRT 类别而收到的。 蛋白质笼动力学对纳米材料的整体性能起着重要作用。该 NIRT 项目将利用工程蛋白笼结构开发结构化纳米材料。研究活动分为三个部分：主动界面、笼动力学和约束。该 NIRT 项目的核心重点是确定活性界面处的粒子限制和蛋白笼动力学如何控制纳米材料的合成和材料功能。 用于纳米材料合成的蛋白质笼结构的开发研究将为未来微电子、催化、传感和医学领域的定向应用阐明基本设计原则。 调查人员将通过密歇根州立大学的本科生学者计划确定来自蒙大拿州的美国原住民学生，并让他们参与该项目。研究人员计划与密歇根州立大学科学和自然历史电影制作项目的学生合作，制作两部有​​关蛋白质笼研究的电影。长期目标是利用所获得的知识来指导新一代活性和响应性纳米材料的开发。具体来说，用于纳米材料合成的蛋白质笼结构的开发研究将揭示未来在微电子、催化、传感和医学领域的定向应用的基本设计原理。