Engineering Principles in Biological Systems

生物系统工程原理

• 批准号: 0709983
• 负责人: Partha Mitra
• 金额: $ 4.78万
• 依托单位: Cold Spring Harbor Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0709983&HistoricalAwards=false
• 关键词: Engineering; Principles; Biological; Systems

ABSTRACT0709983Mitra, ParthaCold Spring Harbor LabEngineering Principles in Bioogical SystemsThree workshops in a series entitled Engineering Principles in Biological Systems are proposed to take place at Cold Spring Harbor Laboratory's Banbury Center, Cold Spring Harbor, NY on May 6-8, 2007, May 4-6, 2008, and May 3-5, 2009. The purpose of these workshops is to bring together scientists with strong theoretical or mathematical backgrounds, and an active interest in applying engineering principles to the study of biological systems, for mutual education and future collaboration. Participants will be drawn from engineering and computer science, biology, and the physical sciences, and their topics of research will span cellular, systems and population biology. Intellectual Merit: Through the process of evolution, living systems retain accidentally found solutions to problems they must solve in order to survive. In the past, theoreticalbiology has largely focused on explanations of the physico-chemical mechanisms behind such solutions, while explanation in the form of function-solution pairs has been studied in a relatively ad hoc manner and has not been approached from a disciplinary perspective. These workshops will promote the development of an emerging approach to theoretical biology with more formal emphasis on design or engineering principles. Here, the premise is that although solutions or designs in biological systems are not engineered but instead arise incrementally through natural selection, they may nevertheless be studied in their existing forms in the framework of engineering theories developed alongside human-engineered systems.Goals of the workshops:(1) Development of a theoretical canon: Refine a list of theories, rather than a theory of everything, applicable to studying engineering principles in biological systems. A starting point for these theories (as reflected in the proposed workshop sessions) can be drawn from courses taught in engineering departments. The idea is therefore to start with major existing engineering theories (controls, communication, computation) and to examine whether these apply to biological systems, and if not, what modifications are in order.(2) Pedagogical goals: The workshops will provide an educational opportunity for biological researchers to learn about engineering theories which may be relevant to their work, and for engineering theorists and computer scientists to learn about biological problems they might help to be understood. Each session will have a tutorial overview of the corresponding engineering theory, followed by biological examples, chosenspecifically to span scales: from cellular and organism levels, as well as from population or evolutionary biology where appropriate. Dissemination and Broader Impact: The proposed workshops will foster this newapproach to understanding biological systems and the collaborative culture across disciplines that its success will require. The conference venue and format are ideal for encouraging open discussion and initiating collaborative efforts, and it is hoped that a continuing series of such workshops will also encourage the development of an enduring and progressive theoretical framework. To complement the direct training opportunity for workshop participants, talks presented at the workshop along with relevant supportingmaterial will be put on a publicly accessible website for the benefit of the general scientific community. In addition, a summary report reflecting the deliberations at the workshop will be prepared and disseminated through the website and submitted for publication in a review journal.

[0709983] mitra， parthold Spring Harbor实验室生物系统工程原理系列研讨会计划于2007年5月6日至8日、2008年5月4日至6日和2009年5月3日至5日在纽约州冷泉港冷泉港实验室班伯里中心举行，主题为“生物系统工程原理”。这些研讨会的目的是将具有强大理论或数学背景，并对将工程原理应用于生物系统研究有积极兴趣的科学家聚集在一起，以便相互教育和未来的合作。参与者将来自工程和计算机科学、生物学和物理科学，他们的研究主题将跨越细胞生物学、系统生物学和种群生物学。智力优势：通过进化的过程，生命系统保留了偶然发现的问题的解决方案，它们必须解决这些问题才能生存。在过去，理论生物学主要集中于解释这些解决方案背后的物理化学机制，而以功能-解决方案对形式的解释以相对特殊的方式进行研究，尚未从学科角度进行研究。这些研讨会将促进理论生物学新方法的发展，更正式地强调设计或工程原理。这里的前提是，尽管生物系统中的解决方案或设计不是工程设计，而是通过自然选择逐步产生的，但它们仍然可以在与人类工程系统一起发展的工程理论框架中以现有形式进行研究。研讨会的目标：(1)理论经典的发展：完善理论的列表，而不是一个理论的一切，适用于研究生物系统的工程原理。这些理论的起点（反映在建议的研讨会会议中）可以从工程部门教授的课程中提取。因此，我们的想法是从现有的主要工程理论（控制、通信、计算）开始，并检查这些理论是否适用于生物系统，如果不适用，则需要进行哪些修改。(2)教学目标：研讨会将为生物学研究人员提供一个学习可能与其工作相关的工程理论的教育机会，并为工程理论家和计算机科学家提供一个学习他们可能有助于理解的生物学问题的机会。每节课都将有相应的工程理论的指导概述，然后是生物学的例子，专门选择跨越尺度：从细胞和有机体水平，以及适当的人口或进化生物学。传播和更广泛的影响：拟议的研讨会将促进这种理解生物系统的新方法以及其成功所需的跨学科合作文化。会议的地点和形式是鼓励公开讨论和发起合作努力的理想场所，希望继续举办一系列这样的讲习班也将鼓励形成持久和进步的理论框架。为了补充讲习班参与者的直接培训机会，讲习班上的演讲以及相关的支持材料将被放在一个公众可访问的网站上，以使整个科学界受益。此外，将编写一份反映讲习班审议情况的摘要报告，并通过网站散发，提交在一份审查刊物上发表。