gamma-Hydroxy-alpha,beta-Acetylenic Esters: Asymmetric Synthesis and Application

有了这个奖项，有机和高分子化学计划支持来自弗吉尼亚大学的李普教授的工作。本研究的重点是开发烯醇化物对映选择性加成反应的催化体系，以制备合成有用的中间体，用于具有可能的医学应用的化合物的全合成。 更广泛的影响：这项研究的更广泛的影响被认为是优秀的，特别是由于推广到高中学生。 研究所正在开发的合成方法也将用于合成药用化合物。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Li Pu from the University of Virginia. This research is focused on the development of catalytic systems for the enantioselective addition of enolates to aldehydes to prepare synthetically useful intermediates for total syntheses of compounds with possible medical applications. Broader Impacts: The Broader Impacts of this research is considered to be excellent, especially due to the outreach to high school students. The synthetic methods being developed by the pI will also be useful in the synthesis of medicinally useful compounds.