Poly(alpha-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides

通过 O-羧酸酐的开环聚合得到聚（α-羟基酸）

• 批准号: 1308485
• 负责人: Jianjun Cheng
• 金额: $ 39万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1308485&HistoricalAwards=false
• 关键词: Poly; alpha; hydroxy; acids; via

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division of the National Science Foundation, Jianjun Cheng at the University of Illinois at Urbana-Champaign aims to develop methods for facile preparation of poly(alpha-hydroxy acids) bearing pendant functionalities. The project will first focus on the design and synthesis of various O-carboxyanhydride monomers containing natural or unnatural amino acid side chains. These monomers will then be used in the development of organo- and metal-catalyzed, living ring-opening polymerization of O-carboxyanhydrides to yield well-defined poly(alpha-hydroxy acids) with functionalized side chains. Finally, some applications of poly(alpha-hydroxy acids), such as their uses in encapsulation, conjugation and membrane penetration, will be explored. The broader impacts and proposed education and outreach activities include mentoring academically underperforming undergraduate students and leading summer education and outreach programs designed for stimulating interest of high school and college students in science and engineering. Polyesters are useful materials encountered in many aspects of everyday life: clothing fiber, plastic bottles, plastic shopping bags, etc. One drawback of many commercial polyesters is that they are not easily modified to form new materials with new properties. In this research project, new classes of polyesters that incorporate different types of chemical groups are developed. Such materials could impact a range of technologies in which plastics are used, such as new technologies for recycling of polyester plastics, the generation of renewable plastics and new functional materials for biomedical applications.

在这项由美国国家科学基金会化学部高分子、超分子和纳米化学计划资助的项目中，伊利诺伊大学香槟分校的郑建军致力于开发简便地制备具有悬挂功能的聚(α-羟基酸)的方法。该项目将首先专注于含有天然或非天然氨基酸侧链的各种O-羧酸酐单体的设计和合成。然后，这些单体将用于开发有机和金属催化的活性开环聚合O-羧酸酐，以生成具有官能化侧链的明确定义的聚(α-羟基酸)。最后，对聚(α-羟基酸)在胶囊化、偶联、膜渗透等方面的应用进行了探讨。更广泛的影响和拟议的教育和推广活动包括指导学业成绩不佳的本科生，以及领导旨在激发高中生和大学生对科学和工程兴趣的暑期教育和推广计划。聚酯是日常生活中的许多有用材料：服装纤维、塑料瓶、塑料购物袋等。许多商业聚酯的一个缺点是它们不容易改性，形成具有新性能的新材料。在这项研究项目中，开发了包含不同类型化学基团的新型聚酯。这种材料可能会影响使用塑料的一系列技术，例如回收聚酯塑料的新技术、可再生塑料的产生以及用于生物医学应用的新功能材料。