Synthesis and Investigation of New Core-Shell Nanoparticles as Molecular Carrier Systems

该联合提案的目的是开发新的树枝状核壳纳米载体的有效合成，并系统地研究分子结构对其在水性体系中的包封和疏水性分子的运输的影响。通过结合关氏集团的专业知识，（UC Irvine，USA），用于一锅法合成具有可控拓扑结构和Haag基团的疏水性聚烯烃核（Freie Universitaet柏林，德国）用于有效合成亲水性和生物相容性聚甘油壳，该研究旨在开发用于合成核-壳纳米载体的有效方法，并揭示基本结构-所得新的两亲性分子结构的性质信息。 从这项研究中获得的对结构-性质关系的理解将为设计高效分子纳米载体提供关键的见解，这些载体可能会在墨水配方和药物递送中找到潜在的应用。有了这个奖项，有机和高分子化学计划和国际科学与工程办公室将支持加州大学化学系管志斌教授的研究，欧文 该奖项与德国研究共同体（DFG）为德国自由大学柏林的Rainer Haag教授资助的合作奖协调。 Guan教授和Haag教授的研究工作围绕着开发用于制备树枝状聚合物的简易合成方法。 这种化学将有助于聚合物合成的环境友好方法，因为该方法是高效的。 该方法的成功开发将对制药工业的药物输送和化学工业的染料封装产生影响。

The objective of this joint proposal is to develop efficient syntheses for new dendritic core-shell nanocarriers and to systematically investigate the effects of molecular architecture on their encapsulation and transport of hydrophobic molecules in aqueous systems. By combining the expertise of the Guan group (UC Irvine, USA) for one-pot synthesis of hydrophobic polyolefin cores with controllable topologies and the Haag group (Freie Universitaet Berlin, Germany) for efficient synthesis of hydrophilic and biocompatible polyglycerol shells, the proposed study intends to develop efficient methodology for the synthesis of core-shell nanocarriers and to reveal basic structure-property information on the resulting new amphiphilic molecular architectures. The understanding of structure-property relationships gained from this study will provide critical insight for designing highly efficient molecular nanocarriers that may find potential applications for ink formulation and drug delivery.With this award, the Organic and Macromolecular Chemistry Program and the Office of International Science and Engineering are supporting the research of Professor Zhibin Guan of the Department of Chemistry at the University of California, Irvine. This award coordinates with a collaborative award funded by Deutsche Forschungsgemeinschaft (DFG) for Professor Rainer Haag, Freie Universitaet Berlin, Germany. Professors Guan and Haag's research efforts revolve around the development of facile synthetic methods for the preparation of dendritic polymers. Such chemistry will contribute to environmentally benign methods for polymer synthesis as the method is highly efficient. Successful development of the methodology will have an impact on drug delivery for pharmaceutical industries and on dye encapsulation for chemical industries.