Probabilistic computing and biological applications

概率计算和生物应用

基本信息

  • 批准号:
    0726969
  • 负责人:
  • 金额:
    $ 75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-01 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

Biological systems hold the key to ultra-powerful computing using just microwatts of power; this research explores emulating this behavior in electrical systems. A novel, biologically inspired computing paradigm is being developed which could fundamentally change scientific and multimedia computing. This new computing approach simultaneously addresses a looming problem in semiconductor systems and many nano-electronics systems; that is, as feature sizes in computer chips are scaled down further, ideal behavior cannot always be guaranteed. In these systems, results of individual operations are described only statistically or probabilistically. A principal point of this research is to embrace probabilistic computing elements rather than to devise ways to make them ideal or deterministic. Recent research suggests that biological and other natural systems are probabilistic in nature. Thus, probabilistic technology provides a novel method to simulate biological, chemical, and neurobiological systems to reach previously unattainable simulation speeds and complexity. Additionally, many multi-media signal processing systems can take advantage of this computing approach to achieve tremendous gains in efficiency at the cost of imperceptible degradation in quality. Probabilistic CMOS (PCMOS) allows a computing circuit to operate probabilistically and, as a result, achieve extreme power savings. A PCMOS circuit is a digital circuit where the supply voltage is lowered to sub-threshold levels; the output of the circuit is correct with some probability p 1. The probabilistic nature of the computation may be artificially imposed or it may be a inevitable result of extreme semiconductor scaling. Furthermore, p can be precisely controlled using extant analog floating gate technology. This research uses PCMOS to perform computations and simulations that either require or can tolerate probabilistic behavior, specifically simulation of biological processes which can be extended to Monte Carlo simulations for any dynamical system. These methods allow orders-of-magnitude speed-up and substantially reduced power consumption. The research involves hardware, algorithmic, and theoretical aspects of probabilistic computing.
生物系统掌握着只用微瓦功率就能实现超强计算的关键;本研究探索了在电气系统中模拟这种行为。一种新颖的、受生物学启发的计算范式正在被开发,它可能从根本上改变科学和多媒体计算。这种新的计算方法同时解决了半导体系统和许多纳米电子系统中迫在眉睫的问题;也就是说,随着计算机芯片的特征尺寸进一步缩小,理想的行为不能总是得到保证。在这些系统中,单个操作的结果仅以统计或概率方式描述。这项研究的一个要点是采用概率计算元素,而不是设计使它们理想或确定的方法。最近的研究表明,生物和其他自然系统在本质上是概率性的。因此,概率技术提供了一种新的方法来模拟生物、化学和神经生物学系统,以达到以前无法实现的模拟速度和复杂性。此外,许多多媒体信号处理系统可以利用这种计算方法以难以察觉的质量下降为代价获得巨大的效率收益。概率CMOS (PCMOS)允许计算电路以概率方式运行,从而实现极低的功耗。PCMOS电路是一种数字电路,其中电源电压降低到亚阈值水平;电路的输出以p 1的概率是正确的。计算的概率性质可能是人为强加的,也可能是极端半导体缩放的必然结果。此外,可以使用现有的模拟浮栅技术精确控制p。本研究使用PCMOS来执行需要或可以容忍概率行为的计算和模拟,特别是生物过程的模拟,可以扩展到任何动态系统的蒙特卡罗模拟。这些方法可以实现数量级的加速,并大大降低功耗。研究涉及硬件,算法和理论方面的概率计算。

项目成果

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专利数量(0)

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David Anderson其他文献

Bilateral arterial ducts with isolated left subclavian artery in ventriculo-arterial discordance, ventricular septal defect, and coarctation.
双侧动脉导管,左锁骨下动脉孤立,存在心室动脉不一致、室间隔缺损和缩窄。
Engineered silver nanoparticles are sensed at the plasma membrane and dramatically modify the physiology of Arabidopsis thaliana plants.
工程银纳米颗粒在质膜上被感应,并显着改变拟南芥植物的生理机能。
  • DOI:
    10.1111/tpj.13105
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Arifa Sosan;D. Svistunenko;Darya Y. Straltsova;Katsiaryna Tsiurkina;I. Smolich;T. Lawson;S. Subramaniam;V. Golovko;David Anderson;A. Sokolik;Ian Colbeck;V. Demidchik
  • 通讯作者:
    V. Demidchik
Harrison’s Principles of Internal Medicine, 16th Edition
哈里森内科医学原理,第 16 版
  • DOI:
    10.1212/01.wnl.0000161677.02570.30
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    9.9
  • 作者:
    David Anderson
  • 通讯作者:
    David Anderson
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
基础科学232.
  • DOI:
    10.1093/rheumatology/kes108
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    5.5
  • 作者:
    S. Heathfield;B. Parker;L. Zeef;I. Bruce;Y. Alexander;F. Collins;M. Stone;E. Wang;Anwen S. Williams;H. L. Wright;Huw B. Thomas;R. Moots;S. Edwards;C. Bullock;V. Chapman;D. Walsh;A. Mobasheri;D. Kendall;S. Kelly;R. Bayley;C. Buckley;S. Young;Lisa Rump;J. Middleton;Liye Chen;R. Fisher;S. Kollnberger;N. Shastri;B. Kessler;P. Bowness;A. N. Moideen;L. Evans;L. Osgood;Simon A. Jones;M. Nowell;Younis Mahadik;S. Young;M. Morgan;C. Gordon;L. Harper;J. Giles;B. Morgan;C. Harris;O. Ryśnik;K. McHugh;S. Payeli;O. Marroquin;J. Shaw;C. Renner;S. Nayar;T. Cloake;M. Bombardieri;C. Pitzalis;C. Buckley;F. Barone;P. Lane;M. Coles;E. Williams;C. Edwards;C. Cooper;R. Oreffo;S. Dunn;A. Crawford;M. Wilkinson;C. Maitre;R. Bunning;J. Daniels;K. Phillips;N. Chiverton;C. Maitre;J. Shaw;A. Ridley;I. Wong;S. Keidel;A. Chan;N. Gullick;H. E. Abozaid;David M. Jayaraj;H. Evans;D. Scott;E. Choy;L. Taams;M. Hickling;G. Golor;A. Jullion;S. Shaw;K. Kretsos;S. F. Bari;Brian Rhys;N. Amos;S. Siebert;R. D. Bunning;G. Haddock;A. Cross;I. Kate;E. Phillips;A. Cross;R. D. Bunning;S. Ceeraz;J. Spencer;E. Choy;V. Corrigall;A. Crilly;H. Palmer;J. Lockhart;R. Plevin;W. Ferrell;I. McInnes;D. Hutchinson;L. Perry;M. Dicicco;F. Humby;S. Kelly;R. Hands;I. McInnes;P. Taylor;P. Mehta;A. Mitchell;C. Tysoe;R. Caswell;M. Owens;T. Vincent;T. Hashmi;A. Price;C. Sharp;H. Murphy;E. F. Wood;T. Doherty;J. Sheldon;N. Sofat;I. Goff;P. Platt;R. Abdulkader;G. Clunie;M. Ismajli;E. Nikiphorou;A. Young;N. Tugnet;J. Dixey;S. Banik;D. Alcorn;J. Hunter;W. Maw;Pravin Patil;F. Hayes;W. Wong;F. Borg;B. Dasgupta;A. Malaviya;A. Östör;J. Chana;Azeem Ahmed;S. Edmonds;L. Coward;F. Borg;J. Heaney;N. Amft;John Simpson;V. Dhillon;Yezenash Ayalew;F. Khattak;M. Gayed;R. Amarasena;F. Mckenna;M. M. Laughlin;K. Baburaj;Zozik Fattah;N. Ng;J. Wilson;B. Colaco;Mark Williams;T. Adizie;Matthew C. Casey;S. Lip;S. Tan;David Anderson;Calum Robertson;I. Devanny;M. Field;D. Walker;S. Robinson;S. Ryan;A. Hassell;J. Bateman;Maggie E. Allen;David Davies;C. Crouch;K. Walker;N. Gainsborough;P. Lutalo;U. Davies;Jennifer R. Mckew;Auleen M Millar;S. Wright;A. Bell;M. Thapper;Thalia Roussou;J. Cumming;R. Hull;J. McKeogh;M. O'connor;Ahmed I. Hassan;U. Bond;J. Swan;M. Phelan;D. Coady;Namita Kumar;L. Farrow;M. Bukhari;A. Oldroyd;C. Greenbank;J. Mcbeth;R. Duncan;Deborah Brown;M. Horan;N. Pendleton;A. Littlewood;L. Cordingley;M. Mulvey;E. Curtis;Z. Cole;S. Crozier;N. Georgia;S. Robinson;K. Godfrey;A. Sayer;H. Inskip;N. Harvey;R. Davies;L. Mercer;J. Galloway;Audrey Low;K. Watson;M. Lunt;D. Symmons;K. Hyrich;S. Chitale;C. Estrach;N. Goodson;E. Rankin;C. Jiang;K. Cheng;T. Lam;P. Adab;S. Ling;J. Humphreys;Corrinne Ellis;D. Bunn;S. Verstappen;Elisa Fluess;G. Macfarlane;C. Bond;G. Jones;I. Scott;S. Steer;C. Lewis;A. Cope;M. Mulvey;K. Lovell;P. Keeley;S. Woby;Marcus John Beasley;S. Viatte;D. Plant;B. Fu;C. Solymossy;J. Worthington;A. Barton;F. Williams;Daniel;M. Popham;A. Macgregor;T. Spector;J. Little;A. Herrick;S. Pushpakom;H. Ennis;H. Mcburney;J. Worthington;W. Newman;I. Ibrahim;A. Morgan;A. Wilson;J. Isaacs;T. Sanderson;S. Hewlett;M. Calnan;M. Morris;K. Raza;Kanta Kumar;C. Cardy;J. Pauling;J. Jenkins;S. Brown;N. McHugh;M. Mugford;C. Davies;N. Cooper;A. Brooksby;E. Dures;N. Ambler;Debbie Fletcher;D. Pope;F. Robinson;R. Rooke;C. Gorman;P. Reynolds;A. Hakim;A. Bosworth;D. Weaver;P. Kiely;S. Skeoch;M. Jani;R. Amarasena;C. Rao;E. Macphie;Y. McLoughlin;P. Shah;S. Else;O. Semenova;Helen Thompson;O. Ogunbambi;S. Kallankara;Y. Patel;E. Baguley;J. Halsey;A. Severn;S. Selvan;E. Price;M. Husain;S. Brophy;C. Phillips;R. Cooksey;Elizabeth Irvine;D. Lendrem;S. Mitchell;S. Bowman;C. Pease;P. Emery;J. Andrews;N. Sutcliffe;P. Lanyon;Monica Gupta;J. McLaren;M. Regan;A. Cooper;I. Giles;D. Isenberg;B. Griffiths;H. Foggo;S. Edgar;S. Vadivelu;W. Ng;I. Iqbal;L. Heron;C. Pilling;J. Marks;J. Ledingham;Chenglong Han;T. Gathany;N. Tandon;E. Hsia;P. Taylor;V. Strand;T. Sensky;N. Harta;S. Fleming;L. Kay;M. Rutherford;K. Nicholl;T. Eyre;G. Wilson;Phil Johnson;M. Russell;J. Timoshanko;G. Duncan;A. Spandley;S. Roskell;Louise West;R. Adshead;S. Donnelly;S. Ashton;H. Tahir;D. Patel;J. Darroch;J. Boulton;Benjamin M Ellis;R. Finlay;W. Murray;R. Priori;T. Tappuni;S. Vartoukian;N. Seoudi;G. Picarelli;F. Fortune;G. Valesini;C. Pitzalis;M. Bombardieri;E. Ball;M. Rooney;A. Bell;Á. Mérida;E. Tarelli;J. Axford;C. Pericleous;S. Pierangeli;J. Ioannou;Anisur Rahman;A. Alavi;M. Hughes;B. Evans;A. Zaki;M. Hui;R. Garner;F. Rees;R. Bavakunji;P. Daniel;S. Varughese;A. Srikanth;M. Andrés;F. Pearce;J. Leung;K. Lim;A. Oomatia;M. Petri;H. Fang;J. Birnbaum;M. Amissah;K. Stewart;H. Jennens;S. Braude;E. Sutton;C. Yee;D. Jayne;M. Akil;Y. Ahmad;D. D'cruz;M. Khamashta;L. Teh;A. Zoma;I. Dey;E. Kenu;A. Garza;L. Murfitt;P. Driscoll;S. Pierangeli;Y. Ioannou;J. Reynolds;D. Ray;T. O'Neill;I. Segeda;S. Shevchuk;I. Kuvikova;N. Brown;M. Venning;M. Dhanjal;J. Mason;C. Nelson;N. Basu;P. Paudyal;Marie Stockton;S. Lawton;C. Dent;Kathy Kindness;G. Meldrum;E. John;C. Arthur;Lucy West;Matthew V. Macfarlane;D. Reid;M. Yates;Y. Loke;R. Watts;D. Christidis;Mark Williams;Rajappa Sivakumar;R. Misra;D. Danda;K. Mahendranath;P. Bacon;S. Mackie
  • 通讯作者:
    S. Mackie
Hemolysis and Thrombocytopenia
溶血和血小板减少
  • DOI:
  • 发表时间:
    2002
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Anderson;J. Kelton
  • 通讯作者:
    J. Kelton

David Anderson的其他文献

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{{ truncateString('David Anderson', 18)}}的其他基金

Arctic Heritage: Commodification, Identity, and Revitilisation in the Anthropocene
北极遗产:人类世的商品化、身份和复兴
  • 批准号:
    AH/Y000161/1
  • 财政年份:
    2023
  • 资助金额:
    $ 75万
  • 项目类别:
    Research Grant
Collaborative Research: Resource Collaborative for Immersive Technologies (RECITE)
协作研究:沉浸式技术资源协作 (RECITE)
  • 批准号:
    2331451
  • 财政年份:
    2023
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant
Technical Workforce Immersive Teaching and Learning Resources
技术人员沉浸式教学资源
  • 批准号:
    2202206
  • 财政年份:
    2022
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant
I-Corps: Analog artificial neural network (ANN) structure with tunable parameters for identification of acoustic events
I-Corps:具有可调参数的模拟人工神经网络 (ANN) 结构,用于识别声学事件
  • 批准号:
    2050117
  • 财政年份:
    2021
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant
Parahydrogen Matrix Isolation Infrared Spectroscopy and Kinetics
仲氢基质分离红外光谱和动力学
  • 批准号:
    2101719
  • 财政年份:
    2021
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant
Reaction Networks: Theory, Computation, and Applications
反应网络:理论、计算和应用
  • 批准号:
    2051498
  • 财政年份:
    2021
  • 资助金额:
    $ 75万
  • 项目类别:
    Continuing Grant
CAREER: Equivariant and Infinite-Dimensional Combinatorial Algebraic Geometry
职业:等变和无限维组合代数几何
  • 批准号:
    1945212
  • 财政年份:
    2020
  • 资助金额:
    $ 75万
  • 项目类别:
    Continuing Grant
SBIR Phase II: Atom-based magnetic field monitor for turbo-generator fault protection
SBIR 第二阶段:用于涡轮发电机故障保护的基于原子的磁场监测器
  • 批准号:
    1951214
  • 财政年份:
    2020
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant
The Political Ecology of Coastal Societies
沿海社会的政治生态
  • 批准号:
    ES/S013806/1
  • 财政年份:
    2019
  • 资助金额:
    $ 75万
  • 项目类别:
    Research Grant
PFI-TT: Using machine listening for non-invasive monitoring of the status and wellbeing of commercial poultry flocks
PFI-TT:使用机器监听对商业家禽群的状态和健康进行非侵入性监测
  • 批准号:
    1919235
  • 财政年份:
    2019
  • 资助金额:
    $ 75万
  • 项目类别:
    Standard Grant

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普适计算环境下基于交互迁移与协作的智能人机交互研究
  • 批准号:
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  • 批准年份:
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    22.0 万元
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  • 批准号:
    90412009
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    2004
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  • 项目类别:
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相似海外基金

CAREER: Computing rules of the social brain: behavioral mechanisms of function and dysfunction in biological collectives
职业:社会大脑的计算规则:生物集体中功能和功能障碍的行为机制
  • 批准号:
    2338596
  • 财政年份:
    2024
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    $ 75万
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    Continuing Grant
Accelerating drug discovery via ML-guided iterative design and optimization
通过机器学习引导的迭代设计和优化加速药物发现
  • 批准号:
    10552325
  • 财政年份:
    2023
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    $ 75万
  • 项目类别:
Bioinformatics Core
生物信息学核心
  • 批准号:
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Developing computational methods to identify of endogenous substrates of E3 ubiquitin ligases and molecular glue degraders
开发计算方法来鉴定 E3 泛素连接酶和分子胶降解剂的内源底物
  • 批准号:
    10678199
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Early life exposure to metal mixtures: impacts on asthma and lungdevelopment
生命早期接触金属混合物:对哮喘和肺部发育的影响
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Cloud-Based Machine Learning and Biomarker Visual Analytics for Salivary Proteomics
基于云的机器学习和唾液蛋白质组生物标志物可视化分析
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Technology Core
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    10715742
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    2023
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