Human and Monkey Studies of Attentional Control Networks

人类和猴子的注意力控制网络研究

• 批准号: 0727115
• 负责人: George Mangun
• 金额: $ 60万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0727115&HistoricalAwards=false
• 关键词: Human; Monkey; Studies; Attentional; Control

Visual selective attention is a core cognitive ability that enables humans and animals to focus on behaviorally relevant stimuli while minimizing interference from irrelevant and/or distracting events. Several current theoretical models have proposed that cortical brain regions interact with subcortical brain structures to form a control network for voluntary attention. This control network exerts modulatory influences over the transmission of the visual signals in the sensory pathways that result in attentional filtering of visual inputs. In particular, the pulvinar, a subcortical thalamic structure, has been implicated as a key part of the attentional control network, but relatively little is known about the neurophysiological mechanisms involved. With support from the National Science Foundation, Dr. George R. Mangun and Dr. W. Martin Usrey of the University of California at Davis will explore the neural mechanisms of attentional control, especially with respect to the role of the subcortical pulvinar nuclei of the thalamus. This project will combine studies in humans and monkeys. In healthy human volunteers, brain scanning using functional and structural magnetic resonance imaging will be used to identify the neuroanatomical systems involved in attentional processing and to assess the role of the pulvinar in attentional control. In awake monkeys, electrical recordings from the pulvinar and early visual cortical areas will be used to investigate the mechanisms of attentional processing at the level of single brain cells and small networks of neurons. Whether driving a car, listening to safety instructions, or concentrating on correctly preparing tax returns, attention supports successful performance. How the brain enables attention is of central interest for understanding how humans and animals function in a complex, and often demanding, environment. This research will test a specific hypothesis about the brain mechanisms that support successful attention. The research will capitalize on combining investigations in different related species (humans and monkeys) and will therefore permit different levels of analysis to be integrated. The activity of single neurons, which cannot easily be studied in humans, will be investigated in monkeys, while widespread human brain networks will be studied using brain imaging in humans. Because the humans and monkeys will be required to perform the same tasks while their brains are being studied, the resulting data from each species and method will be able to be integrated and considered in a common analytical and theoretical framework. The information from this research will provide a basic understanding of an essential ability in human thought and action, and will also provide information that can be used in ameliorating disorders of attention and improving attentional abilities in patients and healthy individuals.

视觉选择性注意是一种核心认知能力，它使人类和动物能够专注于行为相关的刺激，同时最大限度地减少不相关和/或分散注意力的事件的干扰。目前的几个理论模型提出，大脑皮层区域与皮层下的大脑结构相互作用，形成一个控制网络的自愿注意。该控制网络对感觉通路中的视觉信号的传输施加调节影响，导致视觉输入的注意过滤。特别是，枕，一个皮质下丘脑结构，已被牵连的注意力控制网络的关键部分，但相对知之甚少有关的神经生理机制。在美国国家科学基金会的支持下，乔治R. Mangun和W.加州大学戴维斯分校的马丁·乌斯雷将探索注意力控制的神经机制，特别是丘脑皮质下枕核的作用。该项目将结合对人类和猴子的联合收割机研究。在健康的人类志愿者中，使用功能和结构磁共振成像进行大脑扫描，将用于识别参与注意力处理的神经解剖系统，并评估枕在注意力控制中的作用。在清醒的猴子中，来自枕和早期视觉皮层区域的电记录将用于研究单个脑细胞和小神经元网络水平上的注意力处理机制。无论是驾驶汽车，听安全说明，或专注于正确准备纳税申报表，注意力支持成功的表现。大脑如何实现注意力是理解人类和动物在复杂且通常要求苛刻的环境中如何发挥作用的核心兴趣。这项研究将测试一个关于支持成功注意力的大脑机制的特定假设。该研究将利用对不同相关物种（人类和猴子）的综合调查，因此将允许整合不同层次的分析。单个神经元的活动，这在人类中很难研究，将在猴子中进行研究，而广泛的人脑网络将使用人脑成像进行研究。由于人类和猴子在研究大脑时需要执行相同的任务，因此每个物种和方法的结果数据将能够在一个共同的分析和理论框架中进行整合和考虑。这项研究的信息将提供对人类思想和行动的基本能力的基本理解，也将提供可用于改善注意力障碍和改善患者和健康个体注意力能力的信息。