Collaborative Research: DRU: Behavioral and Neural Effects of Sleep Deprivation on Specific Components of Decision Making

项目摘要：合作研究：DRU：睡眠剥夺对决策特定成分的行为和神经效应加利福尼亚大学圣地亚哥分校德拉蒙德，这项研究结合了睡眠，认知神经科学和实验经济学领域的努力。这个项目将检查多种类型的睡眠剥夺对决策的特定组成部分的影响。这项研究将检查睡眠剥夺后在做决定时行为表现和大脑功能的变化。一项控制良好的实验室睡眠剥夺研究将检查26个小时的完全睡眠剥夺（根本没有睡眠）和6个晚上的部分睡眠剥夺（每晚有一些但不足的睡眠）相对于休息良好的条件。受试者将执行决策任务，旨在评估a)风险偏好，b)信息整合，c)概率加权，d)决策过程中的价值处理。比赛时的大脑功能将用功能性磁共振成像来测量。为了确定这些实验室发现在多大程度上可以推广到睡眠剥夺的类型？现实世界吗?，在两个不同的本科院校进行研究。这两项研究将客观地跟踪相对较多的大学生的睡眠（和其他因素），每个为期一周，然后管理决策任务。这些学校的学生平均每晚睡4-7个小时。通过在实验室外研究生态学上自然的睡眠时间范围，人们可以确定这种类型的睡眠缺失是否会产生与实验室中看到的类似的行为变化（可能是大脑功能的变化）。这些实验重现了无数现实世界决策中最核心的基本任务，比如金融或医疗决策或评估环境风险。总之，这三项研究将提供关于睡眠剥夺对决策的影响的丰富信息，并寻求直接评估实验室控制的发现可以推广到现实世界睡眠剥夺模型的程度。

Abstract Project Summary Collaborative Research: DRU: Behavioral and Neural Effects of Sleep Deprivation on Specific Components of Decision Making Drummond,Sean University of California-San Diego This research combines efforts from the fields of sleep, cognitive neuroscience, and experimental economics. This project will examine the impact of multiple types of sleep deprivation on specific components of decision making. The research will examine changes in behavioral performance and brain function during decision after sleep deprivation. A well-controlled laboratory-based sleep deprivation study will examine both 26 hours of total sleep deprivation (no sleep at all) and 6 nights of partial sleep deprivation (some, but insufficient, sleep each night) relative to a well-rested condition. Subjects will perform decision tasks designed to assess a) risk preference, b) information integration, c) probability weighting, and d) value processing during decision making. Brain function during performance will be measured with functional magnetic resonance imaging. To determine the extent to which these laboratory findings can be generalized to the type of sleep deprivation experienced in the ?real world?, the PIs will conduct studies at two separate undergraduate institutions. These two studies will objectively track the sleep (and other factors) of a relatively large number of undergraduates for a week each and then administer the decision tasks. Students at these schools average 4-7 hours of sleep each night. By studying an ecologically natural range of sleep times outside the laboratory, one can determine if this type of sleep loss produces similar behavioral changes (and presumably, brain function changes) as seen in the laboratory. These experiments recreate fundamental tasks that are at the very core of countless real-world decisions, such as financial or medical decisions or evaluating environmental risks. Together, the three studies will provide rich information concerning the effects of sleep deprivation on decision making and seek to directly evaluate the extent to which laboratory-controlled findings can generalize to a real-world model of sleep deprivation.