Collaborative Research: DRU: Behavioral and Neural Effects of Sleep Deprivation on Specific Components of Decision Making

项目摘要合作研究：DRU：睡眠剥夺对决策的特定组成部分的行为和神经影响加州大学圣迭戈分校的肖恩·德拉蒙德这项研究结合了睡眠、认知神经科学和实验经济学领域的努力。这个项目将考察多种类型的睡眠剥夺对决策的特定组成部分的影响。这项研究将检测睡眠剥夺后决策过程中行为表现和大脑功能的变化。一项以实验室为基础的良好控制的睡眠剥夺研究将检查26小时的完全睡眠剥夺(根本不睡觉)和6个晚上的部分睡眠剥夺(一些，但每晚睡眠不足)与休息良好的条件相关。受试者将执行旨在评估a)风险偏好、b)信息整合、c)概率加权和d)决策过程中的价值处理的决策任务。比赛期间的大脑功能将通过功能磁共振成像进行测量。为了确定这些实验室发现在多大程度上可以推广到现实世界中经历的睡眠剥夺类型，PI将在两个不同的本科生机构进行研究。这两项研究将客观地跟踪相对较多的本科生的睡眠(和其他因素)，每个人一周，然后执行决策任务。这些学校的学生平均每晚睡眠时间为4-7小时。通过在实验室外研究生态上自然的睡眠时间范围，人们可以确定这种类型的睡眠不足是否会产生与实验室中看到的类似的行为变化(可能还有大脑功能变化)。这些实验重现了处于无数现实世界决策核心的基本任务，例如金融或医疗决策或评估环境风险。这三项研究将提供关于睡眠剥夺对决策的影响的丰富信息，并寻求直接评估实验室控制的结果在多大程度上可以推广到现实世界的睡眠剥夺模型。

Abstract Project Summary Collaborative Research: DRU: Behavioral and Neural Effects of Sleep Deprivation on Specific Components of Decision Making Drummond,Sean University of California-San Diego This research combines efforts from the fields of sleep, cognitive neuroscience, and experimental economics. This project will examine the impact of multiple types of sleep deprivation on specific components of decision making. The research will examine changes in behavioral performance and brain function during decision after sleep deprivation. A well-controlled laboratory-based sleep deprivation study will examine both 26 hours of total sleep deprivation (no sleep at all) and 6 nights of partial sleep deprivation (some, but insufficient, sleep each night) relative to a well-rested condition. Subjects will perform decision tasks designed to assess a) risk preference, b) information integration, c) probability weighting, and d) value processing during decision making. Brain function during performance will be measured with functional magnetic resonance imaging. To determine the extent to which these laboratory findings can be generalized to the type of sleep deprivation experienced in the ?real world?, the PIs will conduct studies at two separate undergraduate institutions. These two studies will objectively track the sleep (and other factors) of a relatively large number of undergraduates for a week each and then administer the decision tasks. Students at these schools average 4-7 hours of sleep each night. By studying an ecologically natural range of sleep times outside the laboratory, one can determine if this type of sleep loss produces similar behavioral changes (and presumably, brain function changes) as seen in the laboratory. These experiments recreate fundamental tasks that are at the very core of countless real-world decisions, such as financial or medical decisions or evaluating environmental risks. Together, the three studies will provide rich information concerning the effects of sleep deprivation on decision making and seek to directly evaluate the extent to which laboratory-controlled findings can generalize to a real-world model of sleep deprivation.