EXP-SA: Self Powered Explosives Sensors

EXP-SA：自供电爆炸物传感器

• 批准号: 0729810
• 负责人: Shelley Minteer
• 金额: --
• 依托单位: Saint Louis University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-10-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0729810&HistoricalAwards=false
• 关键词: EXP; SA; Self; Powered; Explosives

This research is aimed at developing selective self-powered sensors for the detection of nitroaromatic explosives. Recently, Saint Louis University has developed a biofuel cell that employs mitochondria to catalyze pyruvate oxidation. It is proposed to modify this biofuel cell to be a self-powered sensor for detection of explosives. Mitochondrial function (oxidation of fuel) can be inhibited by the presence of oligomycin, but this inhibition can be selectively uncoupled by low concentrations of nitroaromatic explosives. Therefore, a self-powered sensor that employs oligomycin-treated mitochondria at the anode of a pyruvate powered biofuel cell will be designed. In the absence of explosive, there will be no power generated, but in the presence of explosive, the mitochondria function will be uncoupled and power will be produced as the mitochondria completely oxidize the pyruvate in the fuel compartment of the self-powered sensor. Self-powered sensors would eliminate the need for replacing batteries in sensors and allow for the easier introduction to wireless sensor networks. This research project will also benefit the four high school students each year who will be invited into the laboratory to do research on the project by helping to increase interest in science and develop a better understanding of the research process.

本研究旨在开发用于检测硝基芳香族爆炸物的选择性自供电传感器。最近，圣路易斯大学开发了一种利用线粒体催化丙酮酸氧化的生物燃料电池。有人建议将这种生物燃料电池改造成一种自供电的爆炸物检测传感器。线粒体功能(燃料的氧化)可以被寡霉素的存在所抑制，但这种抑制可以被低浓度的硝基芳香炸药选择性地解偶联。因此，将设计一种在丙酮酸生物燃料电池的阳极上使用寡霉素处理的线粒体的自供电传感器。在没有炸药的情况下，不会产生电力，但在炸药存在的情况下，线粒体的功能会解偶联，产生电力，因为线粒体完全氧化自给式传感器燃料舱中的丙酮酸。自供电传感器将不再需要更换传感器中的电池，并允许更容易地引入无线传感器网络。这项研究项目还将使每年将被邀请到实验室进行项目研究的四名高中生受益，因为这有助于提高人们对科学的兴趣，并更好地了解研究过程。