NSF Center for Synthetic Organic Electrochemistry

NSF 合成有机电化学中心

• 批准号: 2002158
• 负责人: Shelley Minteer
• 金额: $ 2000万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2002158&HistoricalAwards=false
• 关键词: NSF; Center; Synthetic; Organic; Electrochemistry

This center realizes a long-held goal of synthetic chemists: to use electrons as chemical reagents in oxidation reactions (removing electrons) or reduction reactions (adding electrons). There are currently very few cases where this is viable at useful scales and across a range of substrates. The CSOE team brings together synthetic chemists, surface chemists, electroanalytical chemists, theorists, materials scientists and chemical engineers to understand the detailed surface processes happening on a particular electrode and develop creative new chemical reactions. The discoveries, new methodologies and techniques developed in the Center enable safer and sustainable synthetic organic chemistry in both academia and industry. Other broader impacts include graduate and postdoctoral training in team science and entrepreneurship and outreach efforts to underserved audiences including refugee communities. The mission of the NSF Center for Synthetic Organic Electrochemistry (CSOE) is to make synthetic organic electrochemistry mainstream through the invention of enabling, green, safe, and economic new reactions and the demystification of fundamental electrochemical reactivity. Oxidations and reductions are still done with large amounts of oxidizing and reducing agents rather than the greener and more efficient electrochemical methodologies. However, as synthetic organic chemists work toward more sustainable chemistry, preparative electrochemical methods become natural choices due to their high product efficiency, mild conditions, and ease of scalability. Integrating expertise across many areas (electrochemistry, material science, surface science, computational modeling, mechanistic analysis, and synthetic organic chemistry) builds the knowledge base, techniques, and instrumentation to promote widespread adoption of preparative electrochemical methods. This Center has four thrusts. The first thrust develops electrocatalysts and mediators for C-H functionalization. The second thrust develops techniques for oxidative electrosynthesis. The third thrust focuses on methods and materials for reductive electrosynthesis. The fourth thrust applies the new electrosynthesis methods to complex organic synthesis. CSOE also designs instrumentation and electrochemical cells tailored to the needs of the synthetic organic chemist. The integrated and synergistic research environment offers unique opportunities for graduate students and postdoctoral researchers. This training is further enhanced through vibrant partnerships with industry, collaborative training with a diverse set of scientists and engineers, and by engaging in community-wide education and outreach.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该中心实现了合成化学家长期以来的目标：在氧化反应（去除电子）或还原反应（添加电子）中使用电子作为化学试剂。目前，这在有用的规模上和在一系列基质上是可行的情况很少。CSOE团队汇集了合成化学家，表面化学家，电分析化学家，理论家，材料科学家和化学工程师，以了解特定电极上发生的详细表面过程，并开发创造性的新化学反应。该中心开发的发现，新方法和技术使学术界和工业界的合成有机化学更加安全和可持续。其他更广泛的影响包括团队科学和创业精神方面的研究生和博士后培训，以及向包括难民社区在内的服务不足的受众开展的外联工作。NSF合成有机电化学中心（CSOE）的使命是通过发明使能、绿色、安全和经济的新反应以及揭开基本电化学反应的神秘面纱，使合成有机电化学成为主流。氧化和还原仍然使用大量的氧化剂和还原剂，而不是更环保和更有效的电化学方法。然而，随着合成有机化学家朝着更可持续的化学方向努力，制备电化学方法由于其高产品效率，温和的条件和易于扩展性而成为自然选择。整合许多领域（电化学，材料科学，表面科学，计算建模，机械分析和合成有机化学）的专业知识，建立知识库，技术和仪器，以促进制备电化学方法的广泛采用。该中心有四个重点。第一个推力发展电催化剂和调解员的C-H功能化。第二个重点是发展氧化电合成技术。 第三个重点是还原电合成的方法和材料。第四个重点将新的电合成方法应用于复杂有机合成。CSOE还根据合成有机化学家的需要设计仪器和电化学电池。综合和协同的研究环境为研究生和博士后研究人员提供了独特的机会。通过与行业的积极合作、与不同科学家和工程师的合作培训以及参与社区范围的教育和推广活动，进一步加强了这一培训。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Autonomous closed-loop mechanistic investigation of molecular electrochemistry via automation

• DOI: 10.1038/s41467-024-47210-x
• 发表时间: 2024-03-30
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Sheng，Hongyuan;Sun，Jingwen;Liu，Chong
• 通讯作者: Liu，Chong

Overcoming the limitations of Kolbe coupling with waveform-controlled electrosynthesis

• DOI: 10.1126/science.adf4762
• 发表时间: 2023-04-07
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Hioki，Yuta;Costantini，Matteo;Baran，Phil S.
• 通讯作者: Baran，Phil S.

Modular terpene synthesis enabled by mild electrochemical couplings.

• DOI: 10.1126/science.abn1395
• 发表时间: 2022-02-18
• 期刊: Science (New York, N.Y.)

Electroorganic Synthesis in Aqueous Solution via Generation of Strongly Oxidizing and Reducing Intermediates

水溶液中通过生成强氧化性和还原性中间体进行有机电合成

• DOI: 10.1039/d3fd00067b
• 发表时间: 2023
• 期刊: Faraday Discussions
• 影响因子: 3.4
• 作者: Hosseini, Seyyedamirhossein;Beeler, Joshua A;Sanford, Melanie S;White, Henry S
• 通讯作者: White, Henry S

Cobalt-electrocatalytic HAT for functionalization of unsaturated C-C bonds.

• DOI: 10.1038/s41586-022-04595-3
• 发表时间: 2022-05
• 期刊: Nature
• 影响因子: 64.8