CCI Phase I: NSF Synthetic Organic Electrosynthesis Center

在一个代表化学反应步骤的方程式中，从分子中添加或移除单个电子可能看起来很简单。然而，单电子转移之后可能会发生许多非常迅速的复杂化学反应。NSF合成有机电合成中心正在通过理解电子转移过程和随后的化学反应步骤来开发制造分子的新方法。该中心通过使用电子促进化学变化，避免使用昂贵和产生废物的添加化学试剂，从而实现“更绿色”和更可持续的有机合成方法。中心的研究人员还设计了工具和仪器，使这种方法对更大科学界的其他化学家更有用。向研究生和博士后研究助理提供的高级科学培训对人力资源开发产生了更广泛的影响。该中心还通过电池、太阳能电池和电解实验创建了介绍电化学的宣传材料。中心的研究人员在有效的科学传播培训合作，与不同的观众分享这些材料。NSF合成有机电合成中心致力于开发用于有机分子化学合成的新型电化学方法。该中心有三个重点：1）用于碳-氢（C-H）官能化的电催化剂和介体的设计; 2）将交叉偶联反应转化为电合成;以及3）用电化学介体的芳烃官能化。研究活动在科学界和工业界具有广泛的影响。氧化和还原仍然通常使用大量的氧化剂和还原剂来完成，而不是更环保和更有效的电化学方法。随着合成有机化学家致力于更可持续的反应，制备电化学方法由于其高产品效率，温和的条件和易于扩展性而可能成为实现这些合成的自然选择。该中心提供新的电催化剂和协议，同时开发仪器和电化学电池供合成有机化学家使用。向研究生和博士后研究助理提供的高级科学培训对人力资源开发产生了更广泛的影响。该中心还制作宣传材料，通过电池、太阳能电池和电解实验介绍电化学技术。接受过有效科学传播培训的中心研究人员合作与不同的受众分享这些材料。

In an equation that represents a step in a chemical reaction, adding or removing a single electron from a molecule might look simple. However, that single electron transfer can be followed by many complicated chemical reactions that occur very quickly. The NSF Synthetic Organic Electrosynthesis Center is developing new ways of making molecules by understanding both the electron transfer process and the subsequent chemical reaction steps. The Center avoids the use of added chemical reagents that are expensive and generate waste by using electrons to promote chemical changes, leading to "greener" and more sustainable methods for organic synthesis. Center researchers also design the tools and instruments that make this approach more useful to other chemists in the greater scientific community. Broader impacts in the development of human resources result from the advanced scientific training offered to graduate students and postdoctoral research associates. The Center also creates outreach materials that introduce electrochemistry through experimentation with batteries, solar cells and electrolysis. Center researchers trained in effective science communication collaborate to share these materials with diverse audiences. The NSF Synthetic Organic Electrosynthesis Center is focused on developing novel electrochemical methodologies for chemical synthesis of organic molecules. This center has three thrusts: 1) design of electrocatalysts and mediators for carbon-hydrogen (C-H) functionalization; 2) translation of cross-coupling reactions to electrosynthesis; and 3) arene functionalization with electrochemical mediators. Research activities have broader impacts in scientific and industrial communities. Oxidation and reductions are still commonly done using large amounts of oxidizing and reducing agents, rather than greener and more efficient electrochemical methodologies. As synthetic organic chemists work toward more sustainable reactions, preparative electrochemical methods may become a natural choice to effect these syntheses due to their high product efficiency, mild conditions, and ease of scalability. The Center provides new electrocatalysts and protocols while developing instrumentation and electrochemical cells for use by the synthetic organic chemists. Broader impacts in the development of human resources result from the advanced scientific training offered to graduate students and postdoctoral research associates. The Center also creates outreach materials that introduce electrochemical techniques through experimentation with batteries, solar cells and electrolysis. Center researchers trained in effective science communication collaborate to share these materials with diverse audiences.