SGER: Observing the development of biofilm structure under controlled complex flow patterns

SGER：观察受控复杂流动模式下生物膜结构的发展

• 批准号: 0730976
• 负责人: Aaron Packman
• 金额: --
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-11-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730976&HistoricalAwards=false
• 关键词: SGER; Observing; development; biofilm; structure

SGER ProposalCBET 0730976Aaron PackmanNorthwestern UniversityObserving the development of biofilm structure under controlled complex flow patterns The primary objective of this project is to develop and evaluate an innovative experimental system for in situ observation of the coupling of physical, chemical, and biological processes affecting the growth and structure of biofilms. The system will consist of a planar flow cell designed to provide well-controlled flow-induced heterogeneity in flow conditions while allowing direct in situ observation of physical/ chemical conditions by optical sensing techniques and microbial growth by microscopic methods. The system will allow the study of microbal communities of varying degrees of complexity. Current experimental systems for studying biofilms do not allow equal control and observation of all the factors that the proposed device will. Aside from developing a tool for research on biofilms, the project will evaluate the range of flow patterns that can be established and how they affect biofilm growth in the system. Biofilms are virtually ubiquitous in the natural environment and in many built systems, including water distribution systems, treatment plants, ship hulls, and concrete structures for waterways.

SGER提案CBET 0730976 Aaron Packman西北大学观察受控复杂流型下生物膜结构的发展本项目的主要目标是开发和评估一种创新的实验系统，用于原位观察影响生物膜生长和结构的物理、化学和生物过程的耦合。该系统将包括一个平面流动池，旨在提供良好控制的流动诱导的流动条件的异质性，同时允许通过光学传感技术和显微镜方法直接原位观察物理/化学条件和微生物生长。该系统将允许研究不同复杂程度的微生物群落。目前用于研究生物膜的实验系统不允许对所提出的装置将进行的所有因素进行同等的控制和观察。除了开发一种研究生物膜的工具外，该项目还将评估可以建立的流动模式的范围以及它们如何影响系统中生物膜的生长。生物膜在自然环境和许多建筑系统中几乎无处不在，包括配水系统、处理厂、船体和水道的混凝土结构。