Signal transduction of macrophages stimulated with Rhodococcus equi or Pseudomonas aeruginosa as modified by membrane lipid composition

用膜脂质成分修饰的马红球菌或铜绿假单胞菌刺激的巨噬细胞的信号转导

• 批准号: 184098501
• 负责人: Professorin Dr. Julia Schumann
• 金额: --
• 依托单位: Universitätsklinik für Anästhesiologie und Operative Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/184098501?language=en
• 关键词: Signal; transduction; macrophages; stimulated; Rhodococcus

Phagocytosis and killing of pathogens by macrophages is a pivotal point in human andanimal health. Some infectious agents like Rhodococcus equi and Pseudomonasaeruginosa, however, are known to restrain respiratory burst and to survive in themacrophages leading to chronic infections. The diet is one important factor modulatingimmune function. In particular, nutritional fatty acids have an impact on membrane fatty acidcomposition. This provides a link between dietary fatty acid uptake, inflammation andimmunity. The goal of the study is to highlight the impact of membrane composition on basaldefense mechanisms of macrophages against the pathogenic microorganisms R. equi and Paeruginosa as modulated by fatty acid supplementation. This includes respiratory burst,phagocytosis, cytokine release, production of antimicrobial peptides as well as receptor upregulation.The comprehensive proof of these cellular processes should give further insightsinto the mechanisms of pathogen-host-interactions and innate immune response - aknowledge crucial to identify new ways for the therapy of chronic infections linked topersistent pathogens.

巨噬细胞吞噬和杀死病原体是人类和动物健康的关键。然而，一些传染性病原体，如马红球菌和铜绿假单胞菌，已知可以抑制呼吸爆发，并在巨噬细胞中存活，导致慢性感染。饮食是调节免疫功能的一个重要因素。特别是，营养脂肪酸对膜脂肪酸组成有影响。这提供了膳食脂肪酸摄取、炎症和免疫之间的联系。该研究的目的是强调细胞膜组成在脂肪酸补充下对巨噬细胞对致病微生物马氏毛囊菌和绿脓杆菌的基底防御机制的影响。这包括呼吸爆发、吞噬、细胞因子释放、抗菌肽的产生以及受体的上调。对这些细胞过程的全面证明将进一步深入了解病原体-宿主相互作用和先天免疫反应的机制-这些知识对于确定与持久性病原体相关的慢性感染治疗的新方法至关重要。

项目成果

Fatty Acid and Peptide Profiles in Plasma Membrane and Membrane Rafts of PUFA Supplemented RAW264.7 Macrophages

• DOI: 10.1371/journal.pone.0024066
• 发表时间: 2011-08-24
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Schumann, Julia;Leichtle, Alexander;Fuhrmann, Herbert
• 通讯作者: Fuhrmann, Herbert

Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition

• DOI: 10.7717/peerj.4212
• 发表时间: 2018-01-05
• 期刊: PEERJ
• 影响因子: 2.7
• 作者: Hellwing, Christine;Schoeniger, Axel;Schumann, Julia
• 通讯作者: Schumann, Julia

Does plasma membrane lipid composition impact the miRNA-mediated regulation of vascular inflammation?

质膜脂质成分是否影响 miRNA 介导的血管炎症调节？

• DOI: 10.1016/j.mehy.2016.01.012
• 发表时间: 2016
• 期刊: Medical hypotheses
• 影响因子: 4.7
• 作者: Schumann J.

The Impact of Membrane Lipid Composition on Macrophage Activation in the Immune Defense against Rhodococcus equi and Pseudomonas aeruginosa

• DOI: 10.3390/ijms12117510
• 发表时间: 2011-11-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Schoeniger, Axel;Adolph, Stephanie;Schumann, Julia
• 通讯作者: Schumann, Julia