Academic Travel Support for Organizing 2007 MRS Workshop on Multi-scale Materials at the Biological Interface

生态旅游- 0735915;2007年生物界面多尺度材料MRS研讨会学术差旅支持项目负责人：John X.J. Zhang，助理教授，生物医学工程系，机构：美国德克萨斯大学奥斯汀分校这是一笔旅行补助金，用于部分支持10名从事界面研究的美国生物医学、生物力学工程和化学工程初级教员和研究生参加11月26日至30日在马萨诸塞州波士顿举行的2007年生物界面固体专题研讨会。材料科学和生物学的界面在从整个组织结构的力学到引入纳米材料的细胞反应等应用中具有重要意义。生物和生理系统的独特属性产生了关键的相互作用，在实验方案或模型的开发中，以及在盐、免疫系统和对材料模量、组成和表面性质有优先反应的细胞的复杂环境中使用固体材料时，必须考虑到这些相互作用。包括硅衬底、金属、陶瓷和聚合物在内的固态材料越来越多地应用于MEMS/NEMS、纳米级技术和材料，以及植入式诊断医疗设备、组织替代和/或药物输送系统。固体材料因其在生物系统中的广泛应用而受到特别关注。骨骼、牙齿、植物材料和外骨骼具有结构、保护或咀嚼功能。这四个关键主题是在以下领域，侧重于生物环境中材料界面的检查：力学表征和/或建模在多个尺度，特别关注材料之间的模量不匹配；material-fluid交互;超微结构相似或极不相似的两种材料的界面；固体复合材料的时效行为；仿生材料;以及结构在多个尺度上的重要性。材料的生物学耐受性如何，包括生物相容性或毒性、细胞粘附、生物污垢或材料与周围流体或细胞环境之间的化学相互作用等问题。如何通过自然适应改善界面特征；通过表面化学变化；和/或添加氨基酸、多肽、酶或细胞。广泛影响：本次研讨会将汇集生物力学、生物物理学、化学工程、组织工程和分子成像领域的顶尖专家和年轻学者，以及来自更传统的生命科学领域（如解剖学、生物学、化学和医学）的研究人员，以促进固体材料在生物系统中的作用的独特和必要的讨论。本次研讨会旨在通过在从整个组织到单个生物分子的尺度上研究固体界面与生物环境的物理化学相互作用来探索这些问题。NSF CBET的支持将帮助青年学者和学生参加这次国际会议，以促进科学，智力和实践知识的交流，特别是与来自工业界的工程师和科学家。参与活动的同学将获得宝贵的经验；而且，在许多情况下，这将是他们第一次有机会展示和发表他们的作品。组织者还希望确保讨论主题与CBET的优先事项保持一致。

CBET- 0735915; Academic Travel Support for Organizing 2007 MRS Workshop on Multi-scale Materials at the Biological Interface PI: John X.J. Zhang, Assistant Professor, Department of Biomedical Engineering, Institution: The University of Texas of Austin Intellectual Merit: This is a travel grant for partial support for ten U.S. biomedical, biomechanical engineering, and chemical engineering junior faculty and graduate students with research on interfacial aspects to participate in the 2007 MRS Symposium on Solids at the Biological Interface, November 26-30, Boston, MA. The interface of materials science and biology is significant in applications ranging from the mechanics of whole tissue constructs to the cellular response from introduced nanoscale materials. Unique attributes of biological and physiological systems generate critical interactions that must be considered in the development of experimental protocols or models and in the use of solid materials in an environment complicated by the presence of salts, an immune system, and cells with preferential responses to material modulus, composition, and surface properties. Solid-state materials including silicon substrates, metals, ceramics, and polymers are increasingly being implemented in MEMS/NEMS, nanoscale technologies and materials, and in implantable diagnostic medical devices and tissue replacement and/or drug delivery systems. Solid materials are of particular interest due to their wide range of applications within biological systems. Bones, teeth, plant materials, and exoskeletons act in structural, protective, or masticatory functions. The four key topics are in the following areas, focusing on examinations of material interfaces in biological environments with respect to: . Mechanical characterization and/or modeling at multiple scales with particular focus on modulus mismatch between materials; material-fluid interactions; interface of two materials with like or highly dissimilar ultrastructures; time-dependent behavior in solid, composite materials; biomimetic materials; and the importance of structure at multiple scales . How well the material is tolerated by biology, including issues of biocompatibility or toxicity, cell adhesion, biofouling, or chemical interactions between the material from the surrounding fluid or cellular milieu . How interface characteristics are improved via natural adaptation; through the alteration of surface chemistry; and/or the addition of amino acids, peptides, enzymes, or cells . Synthesis and characterization of bioinspired materials systems Broad Impact: This workshop will bring together leading experts and young scholars in biomechanics, biophysics, chemical engineering, tissue engineering, and molecular imaging with researchers from more traditional life-science fields (e.g., anatomy, biology, chemistry, and medicine) to facilitate a unique and necessary discourse on the roles of solid materials in biological systems. This workshop seeks to explore these issues by examining the physico-chemical interaction of solid-state interfaces with biological environments at scales ranging from whole tissues to single biomolecules. The support from NSF CBET will help junior academics and students to participate in this international conference to facilitate an exchange of scientific, intellectual and practical knowledge, in particular with engineers and scientists from industry. Students involved will gain invaluable experience through participation in this event; and, in many cases, this will be their first opportunity to present and publish their work. The organizers also want to ensure the discussion topics align well with CBET priorities.