Academic Travel Support for Organizing 2007 MRS Workshop on Multi-scale Materials at the Biological Interface

CBET-0735915；组织2007年MRS生物界面多尺度材料研讨会的学术差旅支持Pi：John X.J.Zhang，助理教授，机构：德克萨斯大学奥斯汀分校智力：这是一笔旅行补助金，用于部分支持10名具有界面研究的美国生物医学、生物机械工程和化学工程初级教师和研究生参加2007年MRS生物界面固体研讨会，11月26-30日，马萨诸塞州波士顿。材料科学和生物学的接口在从整个组织结构的力学到引入的纳米材料的细胞响应的广泛应用中具有重要意义。生物和生理系统的独特属性产生了关键的相互作用，在制定实验方案或模型以及在复杂的环境中使用固体材料时必须考虑这些相互作用，这些环境包括盐的存在、免疫系统和对材料的模数、组成和表面性质有优先反应的细胞。包括硅衬底、金属、陶瓷和聚合物在内的固态材料越来越多地应用于MEMS/NEMS、纳米级技术和材料，以及植入式诊断医疗设备和组织替代和/或药物输送系统。固体材料因其在生物系统中的广泛应用而引起人们的特别兴趣。骨骼、牙齿、植物材料和外骨骼具有结构、保护或咀嚼功能。这四个关键专题是在以下领域，重点是关于生物环境中的材料界面的审查：在多个尺度上的力学表征和/或建模，特别关注材料之间的模数失配；材料-流体相互作用；具有相似或高度不同超微结构的两种材料的界面；固体、复合材料中随时间变化的行为；仿生材料；以及结构在多个尺度上的重要性。生物对材料的耐受性有多好，包括生物兼容性或毒性、细胞黏附、生物污垢或来自周围流体或细胞环境的材料之间的化学相互作用。如何通过自然适应、通过改变表面化学和/或添加氨基酸、多肽、酶或细胞来改善界面特性。生物灵感材料系统的合成和表征影响广泛：本次研讨会将汇集生物力学、生物物理学、化学工程、组织工程和分子成像领域的顶尖专家和年轻学者，以及来自更传统的生命科学领域(如解剖学、生物学、化学和医学)的研究人员，以促进关于固体材料在生物系统中的作用的独特和必要的讨论。本研讨会试图通过在从整个组织到单个生物分子的范围内审查固态界面与生物环境的物理化学相互作用来探讨这些问题。NSF CBET的支持将帮助初级学者和学生参加这次国际会议，促进科学、智力和实用知识的交流，特别是与来自行业的工程师和科学家的交流。参与这一活动的学生将获得宝贵的经验；在许多情况下，这将是他们展示和发表作品的第一次机会。组织者还希望确保讨论主题与CBET的优先事项保持一致。

CBET- 0735915; Academic Travel Support for Organizing 2007 MRS Workshop on Multi-scale Materials at the Biological Interface PI: John X.J. Zhang, Assistant Professor, Department of Biomedical Engineering, Institution: The University of Texas of Austin Intellectual Merit: This is a travel grant for partial support for ten U.S. biomedical, biomechanical engineering, and chemical engineering junior faculty and graduate students with research on interfacial aspects to participate in the 2007 MRS Symposium on Solids at the Biological Interface, November 26-30, Boston, MA. The interface of materials science and biology is significant in applications ranging from the mechanics of whole tissue constructs to the cellular response from introduced nanoscale materials. Unique attributes of biological and physiological systems generate critical interactions that must be considered in the development of experimental protocols or models and in the use of solid materials in an environment complicated by the presence of salts, an immune system, and cells with preferential responses to material modulus, composition, and surface properties. Solid-state materials including silicon substrates, metals, ceramics, and polymers are increasingly being implemented in MEMS/NEMS, nanoscale technologies and materials, and in implantable diagnostic medical devices and tissue replacement and/or drug delivery systems. Solid materials are of particular interest due to their wide range of applications within biological systems. Bones, teeth, plant materials, and exoskeletons act in structural, protective, or masticatory functions. The four key topics are in the following areas, focusing on examinations of material interfaces in biological environments with respect to: . Mechanical characterization and/or modeling at multiple scales with particular focus on modulus mismatch between materials; material-fluid interactions; interface of two materials with like or highly dissimilar ultrastructures; time-dependent behavior in solid, composite materials; biomimetic materials; and the importance of structure at multiple scales . How well the material is tolerated by biology, including issues of biocompatibility or toxicity, cell adhesion, biofouling, or chemical interactions between the material from the surrounding fluid or cellular milieu . How interface characteristics are improved via natural adaptation; through the alteration of surface chemistry; and/or the addition of amino acids, peptides, enzymes, or cells . Synthesis and characterization of bioinspired materials systems Broad Impact: This workshop will bring together leading experts and young scholars in biomechanics, biophysics, chemical engineering, tissue engineering, and molecular imaging with researchers from more traditional life-science fields (e.g., anatomy, biology, chemistry, and medicine) to facilitate a unique and necessary discourse on the roles of solid materials in biological systems. This workshop seeks to explore these issues by examining the physico-chemical interaction of solid-state interfaces with biological environments at scales ranging from whole tissues to single biomolecules. The support from NSF CBET will help junior academics and students to participate in this international conference to facilitate an exchange of scientific, intellectual and practical knowledge, in particular with engineers and scientists from industry. Students involved will gain invaluable experience through participation in this event; and, in many cases, this will be their first opportunity to present and publish their work. The organizers also want to ensure the discussion topics align well with CBET priorities.