Mesoporous PVDF Thin Film Device for Implantable Cardiac Power Generation

标题：用于植入式心脏发电的介孔PVDF薄膜器件目标：PI将设计灵活的多孔聚合物薄膜发电机，将心脏运动转换为电能，为可植入设备充电非技术：能源消耗和电池更换是永久植入生物医疗设备最具挑战性的问题之一。这项研究解决了与创建坚固、可伸缩、与能量相关的纳米材料和可植入微系统相关的基本问题，这些微系统利用人体心脏的生物力学运动和过程的非凡有效性工作。这项研究在推进该领域方面的潜在好处包括开发一大类可调的纳米材料网络，以在单层纳米材料的水平上定制能量转换特性，并在用于诊断传感、生物标记物识别和治疗性药物输送的高能效生物芯片中潜在的翻译应用。生命科学家、工程研究人员、研究生和本科生将接受生物医学工程关键新兴领域的培训。技术：该项目的目标是为构建和评估各种高度灵活和可整合的多层压电聚合物装置奠定基础，这些装置可以将心脏的机械位移转换为电能。虽然充血性心力衰竭的植入式心脏除颤器(ICD)患者的平均寿命已增加到10年，但自动植入式心脏除颤器(AICD)的电池通常每4-5年需要更换一次，具体取决于起搏程度和/或除颤发生情况。由于更换电池需要手术，这种不匹配造成了巨大的且不断增长的临床和经济负担。延长AICD电池寿命的创新解决方案是利用心脏的强劲能量并将其转换为电能。这一建议的假设是，柔性和可整合的聚偏氟乙烯(PVDF)聚合物薄膜在两个表面和整个本体都包含介孔结构，可以嵌入AICD的电流死隙中，从而通过利用PVDF的压电性将心脏的机械运动转换为电能。研究方法包括：1.设计可与现有AICD引线技术接口的多孔PVDF层构成的柔性微型发电机；2.开发基于3D房车心脏运动的心脏发电装置的计算模型，以实现优化设计和功率效率；3.体外量化发电机的机电耦合呈现在AICD引线上。

Title: Mesoporous PVDF Thin Film Device for Implantable Cardiac Power GenerationGoals: The PI will design flexible porous polymer film power generators that convert cardiac motion into electricity to recharge implantable devices Nontechnical:Energy consumption and battery replacement are among the most challenging problems with permanently implanted biomedical devices. This research addresses the fundamental issues related to the creation of robust, scalable, energy-relevant nanomaterials and implantable microsystems that work with the extraordinary effectiveness of biomechanical motion and processes of the human heart. The potential benefits of the research in advancing the field include the development of a broad class of tunable nanomaterials networks to tailor energy conversion characteristics at the level of a single layer of nanomaterials, with potential translational applications in energy efficient biochips for diagnostic sensing, biomarker identification, and therapeutic drug delivery. Life scientists, engineering researchers, graduate and undergraduate students will be trained in key emerging areas of biomedical engineering.Technical:The objective of this project is to lay the foundation for constructing and evaluating different highly flexible and conformable multilayered piezoelectric polymer devices for converting the mechanical displacement of the heart into electrical energy. While the longevity of an average implantable cardiac defibrillators (ICD) patient with congestive heart failure has increased to 10 years after implantation, the battery for an automatic implantable cardiac defibrillators (AICD) needs to be replaced typically every 4-5 years depending on the degree of pacing and/or occurrence of defibrillation. This mismatch poses a significant and ever growing clinical and economic burden since replacing the battery requires a surgery. An innovative solution to increase AICD battery lifetimes is to harness the robust energy of the heart and convert it to electrical power. The hypothesis of this proposal is that flexible and conformable poly(vinylidene fluoride) (PVDF) polymer films containing mesoporous structures at both surfaces and throughout the bulk can be embedded inside the current dead spaces of the AICD leads to convert the mechanical motion of the heart into electrical energy by exploiting the piezoelectricity of PVDF. The research methods include: 1. Design flexible micro-power generators made of porous PVDF layers that can be interfaced with current AICD lead technology; 2. Develop computational model of cardiac power generation devices based on 3D RV heart motion to allow for optimal design and power efficiency; 3. In vitro quantification of mechano-electrical coupling of the power generator presents to an AICD lead.