Mesoporous PVDF Thin Film Device for Implantable Cardiac Power Generation

标题：用于植入式心脏发电的介孔PVDF薄膜装置目标：PI将设计柔性多孔聚合物薄膜发电机，将心脏运动转化为电能，为植入式装置充电。非技术：能源消耗和电池更换是永久植入生物医学设备中最具挑战性的问题之一。这项研究解决了与创造强大的、可扩展的、与能源相关的纳米材料和可植入的微系统相关的基本问题，这些微系统与人类心脏的生物力学运动和过程的非凡有效性有关。这项研究在推进该领域的潜在好处包括开发一大类可调纳米材料网络，以定制单层纳米材料水平的能量转换特性，并在诊断传感、生物标志物识别和治疗药物输送的能效生物芯片中具有潜在的转化应用。生命科学家、工程研究人员、研究生和本科生将在生物医学工程的关键新兴领域进行培训。技术：本项目的目的是为构建和评估不同的高柔性和高适形的多层压电聚合物装置奠定基础，将心脏的机械位移转化为电能。虽然患有充血性心力衰竭的植入式心脏除颤器（ICD）患者的平均寿命在植入式心脏除颤器（ICD）植入后增加到10年，但自动植入式心脏除颤器（AICD）的电池通常需要每4-5年更换一次，这取决于起搏和/或除颤的发生程度。由于更换电池需要手术，这种不匹配带来了巨大的临床和经济负担。增加AICD电池寿命的创新解决方案是利用心脏的强大能量并将其转换为电能。这一提议的假设是，柔性和适形的聚偏氟乙烯（PVDF）聚合物薄膜在表面和整个体上都含有介孔结构，可以嵌入到AICD导线的电流死区中，通过利用PVDF的压电性将心脏的机械运动转化为电能。研究方法包括：1。设计可与当前AICD引线技术接口的多孔PVDF层柔性微型发电机；2. 开发基于3D RV心脏运动的心脏发电装置的计算模型，以实现最佳设计和功率效率；3. 发电机机电耦合的体外定量给出了一个AICD引线。

Title: Mesoporous PVDF Thin Film Device for Implantable Cardiac Power GenerationGoals: The PI will design flexible porous polymer film power generators that convert cardiac motion into electricity to recharge implantable devices Nontechnical:Energy consumption and battery replacement are among the most challenging problems with permanently implanted biomedical devices. This research addresses the fundamental issues related to the creation of robust, scalable, energy-relevant nanomaterials and implantable microsystems that work with the extraordinary effectiveness of biomechanical motion and processes of the human heart. The potential benefits of the research in advancing the field include the development of a broad class of tunable nanomaterials networks to tailor energy conversion characteristics at the level of a single layer of nanomaterials, with potential translational applications in energy efficient biochips for diagnostic sensing, biomarker identification, and therapeutic drug delivery. Life scientists, engineering researchers, graduate and undergraduate students will be trained in key emerging areas of biomedical engineering.Technical:The objective of this project is to lay the foundation for constructing and evaluating different highly flexible and conformable multilayered piezoelectric polymer devices for converting the mechanical displacement of the heart into electrical energy. While the longevity of an average implantable cardiac defibrillators (ICD) patient with congestive heart failure has increased to 10 years after implantation, the battery for an automatic implantable cardiac defibrillators (AICD) needs to be replaced typically every 4-5 years depending on the degree of pacing and/or occurrence of defibrillation. This mismatch poses a significant and ever growing clinical and economic burden since replacing the battery requires a surgery. An innovative solution to increase AICD battery lifetimes is to harness the robust energy of the heart and convert it to electrical power. The hypothesis of this proposal is that flexible and conformable poly(vinylidene fluoride) (PVDF) polymer films containing mesoporous structures at both surfaces and throughout the bulk can be embedded inside the current dead spaces of the AICD leads to convert the mechanical motion of the heart into electrical energy by exploiting the piezoelectricity of PVDF. The research methods include: 1. Design flexible micro-power generators made of porous PVDF layers that can be interfaced with current AICD lead technology; 2. Develop computational model of cardiac power generation devices based on 3D RV heart motion to allow for optimal design and power efficiency; 3. In vitro quantification of mechano-electrical coupling of the power generator presents to an AICD lead.