EPDT: Nano-scale Light Emitting Diode on Silicon Cantilever for Near-field Microscopy of Nanovectors Biodistribution in Tissues and Living Cells

EPDT：硅悬臂梁上的纳米级发光二极管，用于组织和活细胞中纳米载体生物分布的近场显微镜检查

• 批准号: 0725886
• 负责人: Xiaojing Zhang
• 金额: $ 30万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0725886&HistoricalAwards=false
• 关键词: EPDT; Nano; scale; Light; Emitting

The objective of this research is to characterize the distribution of multi-stage combinatorial directed nanovectors in tissues and living cells for tumor characterization and destruction. The approach is to develop a novel near-field scanning probe with sub-diffraction-limit resolution by directly fabricating nanometer sized light source on patterned silicon probe tip, and to use the probe to identify the molecular signatures of breast tumors.Intellectual Merit: The key technology involves using patterned SOI wafer to create a nanoscale light source on the tip of a MEMS fabricated probe. The light source will be made between a pair of silicon electrodes located on the tip, through electrostatically trapping semiconductor nanoparticles (CdSe/ZnS). The expected optical aperture size is ~10 nm, an order of magnitude reduction from that of an advanced NSOM, which enables high resolution imaging of multimolecular complexes on living cells. The self-illuminating scanning probe can be batch fabricated in an array format, with the potential for electronics integration. Broader Impacts: The proposed architecture will be extendable to imaging the development mechanics of other sub-cellular structures. Understanding development at cellular level is essential for understanding of human diseases caused by defects and errors in development and differentiation pathways. A Texas-wide interdisciplinary collaboration in biomedical engineering research and education has recently been initiated. This proposal reflects the inter-institutional goal to conduct cutting-edge research to advance the field of micro-nano scale photonics and MEMS for novel biomedical imaging, to provide outstanding teaching for students, and to attract minority especially Hispanic students into engineering professions.

这项研究的目的是表征组织和活细胞中多阶段组合定向的纳米分离器的分布，以进行肿瘤的表征和破坏。该方法是通过直接在图案化的硅探针尖端制造纳米大小的光源来开发一种新型的近距离扫描探针，并使用探针来识别乳房肿瘤的分子特征。智能技术优点：使用Patterned Soi wafer创建nanscele Light of Mems fign of Mems tip in Tims tip nip in tip of Mems inte tip nims intimectual。光源将通过静电捕获的半导体纳米颗粒（CDSE/ZNS）之间的一对位于尖端上的硅电极之间制成。预期的光孔径尺寸为〜10 nm，比晚期NSOM的数量级降低，这可以使活细胞上的多分子复合物进行高分辨率成像。可以以阵列格式制造自缩扫描探针，并具有电子积分的潜力。更广泛的影响：所提出的结构将扩展到成像其他亚细胞结构的发展力学。了解细胞水平的发展对于理解由发育和分化途径中的缺陷和错误引起的人类疾病至关重要。最近启动了德克萨斯州生物医学工程研究和教育方面的跨学科合作。该提案反映了进行尖端研究的机构间目标，以推进新型生物医学成像的微纳米量表光子学和MEMS领域，为学生提供出色的教学，并吸引少数群体，尤其是西班牙裔学生进入工程专业。