CAREER: Multiphysics Modeling and Experiments for Pulastile Membrane Sensors

由于目前缺乏诊断工具来动态监测手术植入支架动脉的机械状态，以允许适当的心血管血流，因此提出了CAREER建议。将开发多物理场模型并进行实验，以研究原位聚合物传感器支架动脉的力学。研究工作的目标是：(1)用于评估大应变脉冲膜传感器的三维多物理场框架；(2)用于预测传感器输出与动脉闭塞和硬化不同阶段之间相关性的耦合结构-传感器模型。这项工作有望弥合血管机械反应和血管健康现状之间的差距，并量子跃迁原位健康监测能力，使关键的临床医生能够通过多功能传感器进行干预。

This CAREER proposal is motivated by the current lack of diagnostic tools to dynamically monitor the mechanical state of the stented artery that is surgically implanted to allow proper cardiovascular flow. Multiphysics models will be developed and experiments carried out to study the mechanics of a stented artery with an in situ polymer sensor. The research effort is targeted towards development of: (1) a 3-D multiphysics framework for evaluating large strain pulsatile membrane sensors and (2) a coupled structure-sensor model to predict the correlation between sensor output and the varying stage of artery occlusion and rigidification.The proposed work is anticipated to bridge the gap between vascular mechanical response and the current state of vascular health, and quantum jump the in situ health monitoring capability to enable critical clinician intervention through multifunctional sensors.