CAREER: Time-Resolved Condensed Phase Reaction Dynamics Investigated by Multidimensional Infrared Spectroscopy

职业：通过多维红外光谱研究时间分辨凝聚相反应动力学

• 批准号: 0748501
• 负责人: Kevin Kubarych
• 金额: $ 61.5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748501&HistoricalAwards=false
• 关键词: CAREER; Time; Resolved; Condensed; Phase

In this award, funded by the Experimental Physical Chemistry Program of the Division of Chemistry, the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, and the BIO Venture Fund for Interdisciplinary Research (VIR), Professor Kevin J. Kubarych of the University of Michigan, his postdoctoral fellows and graduate and undergraduate students are investigating the dynamics of the bacteriorhodopsin photocycle over six decades of timescale -- femtosecond to microsecond. The principal tool for these studies will be multidimensional infrared (MDIR) spectroscopy. The ultimate goal of the work by Professor Kubarych and his group is to develop a fundamental chemical understanding of how biomolecules move and perform their unique biological functions. Bacteriorhodopsin is a well-studied system, and presents a unique laboratory for new experimental methods. Although well-studied, there are a number of outstanding questions for how bacteriorhodpsin works, and Prof. Kubarych's group's work will help to provide answers. In addition to his research work, Prof. Kubarych plans to bring cutting-edge technology from his laboratory, in the form of femtosecond spectroscopy instrumentation, into the undergraduate teaching laboratory.

在这个由化学系实验物理化学项目、分子和细胞生物科学系分子生物物理项目以及跨学科研究BIO风险基金（VIR）资助的奖项中，密歇根大学Kevin J. Kubarych教授他的博士后研究员、研究生和本科生正在研究细菌视紫红质光循环的动力学，时间尺度--飞秒到微秒。 这些研究的主要工具将是多维红外光谱。Kubarych教授和他的团队工作的最终目标是发展对生物分子如何移动和执行其独特生物功能的基本化学理解。 细菌视紫红质是一个被充分研究的系统，并为新的实验方法提供了一个独特的实验室。 尽管已经进行了充分的研究，但细菌视紫红质是如何工作的，还有一些悬而未决的问题，Kubarych教授的研究小组的工作将有助于提供答案。 除了他的研究工作，Kubarych教授计划从他的实验室带来尖端技术，在飞秒光谱仪器的形式，进入本科教学实验室。