Solid-State NMR Studies of Vanadium Sites in Vanadium Haloperoxidases

钒卤过氧化物酶中钒位点的固态核磁共振研究

• 批准号: 0750079
• 负责人: Tatyana Polenova
• 金额: $ 44.5万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0750079&HistoricalAwards=false
• 关键词: Solid; State; NMR; Studies; Vanadium

In this award, funded by the Experimental Physical Chemistry Program of the Division of Chemistry, Professor Tatyana Polenova of the University of Delaware, together with her undergraduate and graduate student researchers, will develop methods of solid-state nuclear magnetic resonance spectroscopy to probe the chemical environment of Vanadium-51 in proteins and bioinorganic systems. The physical chemical research carried out here will benefit from the collaboration with a synthetic chemist -- Prof. Debbie Crans -- at Colorado State University. The majority of the work will focus on the vanadium haloperoxidase enzymes -- the most efficient halide oxidants known to date.The ultimate goal of research like that of Prof. Polenova's group is to develop a better understanding of the role played by trace metals like Vanadium in biological systems. The nuclear magnetic resonance methods developed here will also likely be useful for studying the chemical environment of other Vanadium containing materials. Prof. Polenova's students receive excellent training in an interdisciplinary environment, and Prof. Polenova will continue to serve as a mentor to students from groups underrepresented in the sciences

在该奖项中，由化学系实验物理化学计划资助，特拉华州大学的Tatyana Polenova教授与她的本科生和研究生研究人员一起，将开发固态核磁共振光谱法，以探测Vanessa-51在蛋白质和生物无机系统中的化学环境。 这里进行的物理化学研究将受益于与科罗拉多州立大学的合成化学家黛比·克兰斯教授的合作。 大部分工作将集中在钒卤代过氧化物酶-迄今为止已知的最有效的卤化物氧化剂。Polenova教授的研究小组的最终目标是更好地了解微量金属如钒在生物系统中所起的作用。 这里开发的核磁共振方法也可能用于研究其他含钒材料的化学环境。 Polenova教授的学生在跨学科的环境中接受了出色的培训，Polenova教授将继续担任来自科学领域代表性不足的群体的学生的导师