Elucidating the Roles of Structurally Directed Electron Induction and Transannulation in Polycyclic Lewis Base and Lewis Acid Catalysis

阐明结构定向电子感应和跨环化在多环路易斯碱和路易斯酸催化中的作用

• 批准号: 0750463
• 负责人: John Verkade
• 金额: $ 30.8万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0750463&HistoricalAwards=false
• 关键词: Elucidating; Roles; Structurally; Directed; Electron

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports investigations by Professor John G. Verkade at the Iowa State University, Ames, Iowa. The intellectual merit of this proposal lies in his current development of two new types of powerful catalysts for industrially important reactions. These catalyst types are based on the new organophosphorus and on the new organo-aluminum compounds he is synthesizing. The structures of these catalyst molecules are designed to incorporate a novel electronic feature that enhances their catalytic activity. The catalyst molecules are also designed to be attached with strong chemical bonds to special solid supports. Such solid-supported catalysts can be recycled many times in either batch or flow reactors. A broad impact of the work supported by this award is that, in terms of economic and environmental considerations, methodologies for important organic reactions will be improved through higher catalyst activity (resulting in lower amounts of catalyst required), the absence of heavy (toxic) metals in the catalysts, and higher product yields under less energy-intensive conditions. The award's second impact is that undergraduate, graduate and post doctoral students as well as visiting professors will continue to be educated and trained in this academically and industrially important area.

这个奖项在无机，生物无机和有机化学计划支持研究教授约翰G。Verkade在爱荷华州艾姆斯的爱荷华州州立大学。这一建议的学术价值在于他目前开发了两种新型的强催化剂，用于工业上重要的反应。这些催化剂类型是基于他正在合成的新的有机磷和新的有机铝化合物。这些催化剂分子的结构被设计成结合了增强其催化活性的新的电子特征。 催化剂分子也被设计成通过强化学键连接到特殊的固体载体上。 这种固体负载型催化剂可以在间歇式或流动式反应器中循环多次。该奖项所支持的工作的广泛影响是，在经济和环境方面，重要有机反应的方法将通过更高的催化剂活性（导致所需的催化剂量更低），催化剂中不含重（有毒）金属以及在能源密集度较低的条件下更高的产品收率得到改进。该奖项的第二个影响是，本科生，研究生和博士后学生以及客座教授将继续在这一学术和工业重要领域接受教育和培训。