A Novel Cardiac Electrical Imaging Approach from Intracavity Recordings

该研究项目的长期目标是通过腔内记录建立一种高分辨率的三维心脏电成像技术，该技术可以在临床导管消融过程中绘制三维心脏（3-D）内的心脏电活动。仅在美国，每年就有近40万人因室性心动过速和心室颤动而猝死。有效的成像技术的发展对于预防和治疗这些恶性心律失常的介入方法的发展至关重要。该方法的新颖之处在于从腔内导管记录中成像三维心电活动，目前在临床电生理实验室广泛应用于心律失常的治疗。动物模型的初步结果表明，通过导管记录重建整个三维心肌的激活序列是可行的，并证明了所提出研究的可行性。

The long-term goal of this proposed research project is to establish a high-resolution 3-dimensional cardiac electrical imaging technology from intra-cavity recordings, that can mapcardiac electrical activity within the 3-dimensional (3-D) heart during clinical catheter ablationprocedures. Sudden death from ventricular tachycardia and ventricular fibrillation claims nearly400,000 lives each year in the United States alone. Development of effective imaging technologies is critical in the evolution of interventional approaches to prevent and treat these malignant arrhythmias.Novel to the proposed approach is to image 3-D cardiac electrical activity from the intra-cavity catheter recordings which are currently widely practiced in clinical electrophysiology labs to manage cardiac arrhythmias. Preliminary results in an animal model, has demonstrated the feasibility of the reconstruction of activation sequence throughout the 3-D myocardium from catheter recordings and attest to the feasibility of the proposed studies.