BRAIN EAGER: High-resolution multimodal acousto-electromagnetic neuroimaging of brain activity

BRAIN EAGER：大脑活动的高分辨率多模态声电磁神经成像

• 批准号: 1450956
• 负责人: Bin He
• 金额: $ 30万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1450956&HistoricalAwards=false
• 关键词: BRAIN; EAGER; resolution; multimodal; acousto

PI: He, Bin Proposal: 1450956 Title: BRAIN EAGER: High-resolution multimodal acousto-electromagnetic neuroimaging of brain activity Significance Brain activity resulting from neuronal excitation is distributed over the 3-dimensional volume and evolves in time. There is a strong need to map the spatio-temporal distributions of brain activation noninvasively. The proposed project aims at developing a groundbreaking technology for neuroimaging of brain activity with high resolution in both space and time. The successful completion of the proposed exploratory project may lead to a transformative neuroimaging modality that would change the practice of functional neuroimaging and offer an extremely desirable high spatio-temporal resolution neuroimaging capability to noninvasively map dynamic neural information processing within the brain at neural circuits level. Such capability will have the potential to transform the current state-of-art that neuroimaging is carried out using separate modalities that can map brain activity either with high spatial or high temporal resolution, but unable to map dynamic brain activation with both high spatial resolution and high temporal resolution. This is of significant impact to human brain mapping, a grand challenge in the BRAIN Initiative. Technical Description The PIs propose to develop a novel hybrid multimodal neuroimaging technology "acousto-electromagnetic neuroimaging" by fully integrating focused ultrasound with electromagnetic sensing and imaging for mapping dynamic brain activation. The proposed imaging technology has the potential to achieve millimeter spatial resolution and millisecond temporal resolution in a single hybrid neuroimaging system for mapping brain activation noninvasively in subjects throughout the lifespan. The central hypothesis is that using focused ultrasound modulation and electromagnetic sensing and source imaging, the PIs will be able to noninvasively detect and image dynamic brain activation and function at neural circuits level in the brain. The specific aims of the proposed project are as follows. Aim 1: Test the proposed acousto-electric neuroimaging in a rat model. In this aim, the investigators will use focused ultrasound to modulate regional neural activity and record the induced electrophysiological signals using an electrode-array. The investigators will decode the neural signals from ultrasound modulated electrical measurements and reconstruct the neural activation to test the hypothesis that the proposed imaging will reveal high spatio-temporal pattern of neural activation. Aim 2: Test the proposed acousto-magnetic neuroimaging in a rat model. In this aim, the investigators will use focused ultrasound to modulate regional neural activity and record the induced electrophysiological signals using a spintronic magnetic sensor array. They will decode the neural signals from ultrasound modulated magnetic measurements and reconstruct the neural activation to test the hypothesis that the proposed imaging will reveal neural activation at a high spatio-temporal pattern.

题目：BRAIN EAGER：脑活动的高分辨率多模态声电磁神经成像意义神经元兴奋引起的脑活动分布在三维体积上，并随时间演化。目前迫切需要无创性地绘制大脑活动的时空分布。该项目旨在开发一种开创性的技术，用于在空间和时间上都具有高分辨率的大脑活动神经成像。该探索性项目的成功完成可能会导致一种变革性的神经成像模式，这将改变功能性神经成像的实践，并提供一种非常理想的高时空分辨率神经成像能力，以非侵入性地绘制大脑内神经回路水平的动态神经信息处理。这种能力将有可能改变目前的现状，即神经成像使用单独的模式进行，可以用高空间分辨率或高时间分辨率绘制大脑活动，但无法同时用高空间分辨率和高时间分辨率绘制动态大脑活动。这对人类大脑图谱的绘制有着重大的影响，这是brain计划的一个重大挑战。PIs建议开发一种新的混合多模态神经成像技术“声-电磁神经成像”，通过将聚焦超声与电磁传感和成像完全集成来绘制动态大脑激活。所提出的成像技术有可能在一个单一的混合神经成像系统中实现毫米空间分辨率和毫秒时间分辨率，用于无创性地绘制受试者整个生命周期的大脑活动。中心假设是，使用聚焦超声调制、电磁传感和源成像，pi将能够在大脑神经回路水平上无创地检测和成像动态大脑激活和功能。拟建项目的具体目的如下。目的1：在大鼠模型上验证所提出的声电神经成像方法。为此，研究人员将使用聚焦超声来调节区域神经活动，并使用电极阵列记录诱发的电生理信号。研究人员将解码来自超声调制电测量的神经信号，并重建神经激活，以验证所提出的成像将揭示神经激活的高时空模式的假设。目的2：在大鼠模型上验证声磁神经成像方法。为此，研究人员将使用聚焦超声来调节区域神经活动，并使用自旋电子磁传感器阵列记录诱导的电生理信号。他们将解码来自超声调制磁测量的神经信号，并重建神经激活，以验证所提出的成像将显示高时空模式下的神经激活的假设。