IPY: Metabolic adaptation among indigenous Siberians: Causes and consequences

IPY：西伯利亚原住民的代谢适应：原因和后果

• 批准号: 0802390
• 负责人: James Snodgrass
• 金额: $ 16.69万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0802390&HistoricalAwards=false
• 关键词: IPY; Metabolic; adaptation; among; indigenous

The project, PI James J. Snodgrass, proposes to address a long standing interest among polar scientists in the adaptability and physiology of humans in the Arctic. The project will focus on the nature of basal metabolic rates (BMR) in Arctic peoples. Existing data from numerous research studies shows that metabolic elevation is an apparent physiological adaptation to cold stress, however, the causal relationship and the mechanisms of this elevation are poorly understood. The proposed research will 1) investigate metabolic elevation and seasonal energy dynamics; 2) clarify hormonal factors associated with metabolic elevation; and 3) consider whether metabolic elevation shapes chronic disease patterns among Arctic populations.

该项目，PI詹姆斯J.斯堪的纳维亚草，提出解决极地科学家长期以来对北极人类适应性和生理学的兴趣。该项目将侧重于北极人民基础代谢率的性质。现有的大量研究数据表明，代谢升高是对冷应激的一种明显的生理适应，然而，这种升高的因果关系和机制却知之甚少。拟议的研究将1）调查代谢升高和季节性能量动态; 2）澄清与代谢升高相关的激素因素; 3）考虑代谢升高是否会影响北极人群的慢性疾病模式。