DISSERTATION RESEARCH: Genetic causes of hybrid sterility

论文研究：杂种不育的遗传原因

• 批准号: 0808029
• 负责人: Mohamed Noor
• 金额: $ 1.2万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808029&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Genetic; causes; hybrid

The process of species formation is the chief source of biodiversity on Earth. Species formation occurs when two populations are no longer capable of producing offspring that are fertile or viable. Sterility of hybrid offspring is thought to result from incompatibilities between the genomes of the two parent species. This proposal examines the genetic architecture of hybrid sterility between two species of fruit flies. Specifically, the proposed research will utilize results from a previous genetic mapping study to examine the nature of interactions within and between genes that confer hybrid male sterility between Drosophila persimilis and D. pseudoobscura bogotana. Furthermore, it will also address a novel model for the evolution of hybrid sterility in another fruit fly species pair. The mechanisms by which species formation occurs have remained largely unresolved since Darwin first alluded to the problem in On the Origin of Species. This research will provide insight on how incongruities between diverging genomes can lead to hybrid dysfunction; such hybrid incompatibilities serve to generate new species and maintain distinct species. Understanding these mechanisms has become especially pertinent in the face of the extinction of many species by human activity.

物种形成的过程是地球上生物多样性的主要来源。 物种形成发生在两个种群不再能够产生可育或可生存的后代时。 杂交后代的不育性被认为是由两个亲本物种的基因组之间的不相容性造成的。 本研究旨在探讨两种果蝇杂交不育的遗传结构。 具体来说，拟议的研究将利用先前遗传图谱研究的结果，研究赋予果蝇和果蝇之间杂交雄性不育的基因内部和之间的相互作用的性质。拟暗花芹 此外，它还将解决另一种果蝇物种对杂交不育性进化的新模型。 自从达尔文在《物种起源》中首次提到这个问题以来，物种形成的机制在很大程度上仍然没有得到解决。 这项研究将提供关于不同基因组之间的不一致如何导致杂交功能障碍的见解;这种杂交不相容性有助于产生新物种并保持不同的物种。 在人类活动导致许多物种灭绝的情况下，了解这些机制变得尤为重要。