Nitrile Anions: Uunmasking Fundamental Reactivity

该项目将继续开发金属化腈的新型立体选择性烷基化反应。 将寻求产生腈阴离子的新方法，特别关注环境友好的烷基化。 烯烃烷基化反应的详细机理分析将作为开发密集取代的双环酮的一般合成的前奏。 从这些反应的基本见解将被用来开发一个手性烷基化策略组装连续的叔-季立体中心。 有了这个奖项，有机和高分子化学计划是支持教授弗雷泽F。迪克讷大学化学系的弗莱明说。 弗莱明教授的研究重点是金属化腈的新反应，这些反应无法通过相应羰基衍生物的烷基化来实现。 该化学将有助于环境友好的化学合成方法，解决合成受阻手性中心的长期困难，并提供对金属化腈性质的基本见解。 实现这些目标将影响制药和农业工业特别感兴趣的小有机分子的合成。

This project will continue the development of new stereoselective alkylations of metalated nitriles. New methods of generating nitrile anions will be pursued with particular attention on environmentally benign alkylations. Detailed mechanistic analysis of alkene alkylations will be undertaken as a prelude to developing a general synthesis of densely substituted bicyclic ketones. Fundamental insight from these reactions will be used to develop a chiral alkylation strategy for assembling contiguous tertiary-quaternary stereocenters. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Fraser F. Fleming of the Department of Chemistry at Duquesne University. Professor Fleming's research focuses on new reactions of metalated nitriles that are unable to be achieved through alkylation of the corresponding carbonyl derivatives. The chemistry will contribute to environmentally benign methods for chemical synthesis, address the long-standing difficulty of synthesizing hindered chiral centers, and provide fundamental insight into the nature of metalated nitriles. Achieving these goals will impact the synthesis of small organic molecules of particular interest to pharmaceutical and agricultural industries.