Functional Genomics of a Dietary Shift in a Mammalian Herbivore: Creosote Feeding in Neotoma Lepida
哺乳动物草食动物饮食转变的功能基因组学:Neotoma Lepida 的杂酚油喂养
基本信息
- 批准号:0817527
- 负责人:
- 金额:$ 36.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-15 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Principal Investigators: Dr. M. Denise Dearing, Dr. Kirk ThomasProject Number: IOS-0817527TITLE: Functional Genomics of a Dietary Shift in a Mammalian Herbivore: Creosote Feeding in Neotoma lepidaFor mammals that consume plants, one of the greatest challenges in shifting from one diet to another is the detoxification of novel plant toxins. We propose to advance our knowledge of the mechanisms used by mammalian herbivores by capitalizing on population differences in the feeding behavior of the desert woodrat. Approximately 11,000 before present, populations of desert woodrats occupying what is now the Mojave desert, underwent a major shift from feeding on a diet of juniper to that of a natural invader, creosote. Populations of woodrats that currently live in the Mojave have adapted to highly toxic creosote as evidenced by their ability to ingest greater quantities of creosote compared to populations that have no prior experience. In this project, the investigators will determine the underlying mechanisms for this difference in ability to process creosote. The investigators will use a combination of approaches from pharmacology and molecular ecology as well as cutting edge genomics techniques. The investigators expect to find specific liver enzymes that convey the ability to consume creosote toxins. The differences in liver enzymes between woodrats may be valuable in explaining differences among human populations in the metabolism of pharmaceutical and nutraceutical compounds. This work will promote the understanding of how mammals adapt to radical changes in diet after natural climate change. The data can be extrapolated to predicting how woodrats will respond to current and future climate change. One of the broader impacts is a contribution to scientific infrastructure in the form of a transcriptome of a non-model organism that will be available to other scientists. The investigators are committed to scientific outreach and participate in one or more outreach events annually in the community (e.g., science fairs, public lectures). The project will provide cutting edge, interdisciplinary training for a postdoctoral fellow, graduate students, undergraduates, summer high school students and for an assistant professor from an undergraduate institution. Trainees on this project will come from underrepresented groups in science, e.g., women and ethnic minorities.
主要研究者:M. Denise Dearing,Dr. Kirk Killas项目编号:IOS-0817527标题:食草哺乳动物饮食转变的功能基因组学:Neotoma lepidaCreosote喂养对于食用植物的哺乳动物来说,从一种饮食转变到另一种饮食的最大挑战之一是新型植物毒素的解毒。 我们建议利用沙漠林鼠的摄食行为的种群差异,以提高我们对哺乳动物食草动物所使用的机制的认识。 大约在11,000年前,占据现在的莫哈韦沙漠的沙漠林鼠种群经历了一个重大转变,从以杜松为食转变为以天然入侵者木馏油为食。目前生活在莫哈韦的林鼠种群已经适应了剧毒的杂酚油,这可以从它们与以前没有经验的种群相比能够摄入更大量的杂酚油中得到证明。在这个项目中,研究人员将确定这种处理杂酚油能力差异的潜在机制。 研究人员将使用药理学和分子生态学以及尖端基因组学技术相结合的方法。 研究人员希望找到特定的肝酶,传达消耗杂酚油毒素的能力。 林鼠之间肝酶的差异可能是有价值的,在解释人类种群之间的药物和营养化合物的代谢差异。 这项工作将促进对自然气候变化后哺乳动物如何适应饮食急剧变化的理解。 这些数据可以外推到预测林鼠将如何应对当前和未来的气候变化。 更广泛的影响之一是对科学基础设施的贡献,其形式是非模式生物的转录组,将提供给其他科学家。 研究者致力于科学推广,每年参加一次或多次社区推广活动(例如,科学展览会、公开讲座)。 该项目将为博士后研究员、研究生、本科生、暑期高中生和本科院校的助理教授提供尖端的跨学科培训。该项目的受训人员将来自科学界代表性不足的群体,例如,妇女和少数民族。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maria Denise Dearing其他文献
Maria Denise Dearing的其他文献
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{{ truncateString('Maria Denise Dearing', 18)}}的其他基金
Intergovernmental Personnel Act Award
政府间人事法奖
- 批准号:
2236697 - 财政年份:2022
- 资助金额:
$ 36.46万 - 项目类别:
Intergovernmental Personnel Award
Meeting: With a Little help from my Friends: Microbial Partners in Integrative and Comparative Biology, a Symposium for the Society for Integrative and Comparative Biology (SICB)
会议:在我的朋友们的帮助下:综合与比较生物学中的微生物合作伙伴,综合与比较生物学学会(SICB)研讨会
- 批准号:
1638630 - 财政年份:2016
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
Collaborative Research: A Comprehensive Study of the Structure, Function, and Diversity of Detoxification Enzymes (CYP2B) in Mammalian Herbivores (Neotoma)
合作研究:哺乳动物草食动物(Neotoma)解毒酶(CYP2B)结构、功能和多样性的综合研究
- 批准号:
1256383 - 财政年份:2013
- 资助金额:
$ 36.46万 - 项目类别:
Continuing Grant
Dimensions: Biodiversity of the Gut Microbiome of Herbivorous Rodents
维度:草食性啮齿动物肠道微生物组的生物多样性
- 批准号:
1342615 - 财政年份:2013
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Biodiversity and community ecology of the gut microbiota in herbivores with respect to dietary toxins
论文研究:食草动物肠道微生物群的生物多样性和群落生态学与膳食毒素的关系
- 批准号:
1210094 - 财政年份:2012
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
The Effect of Anthropogenic Disturbance on the Dynamics of Sin Nombre
人为干扰对 Sin Nombre 动态的影响
- 批准号:
0326999 - 财政年份:2004
- 资助金额:
$ 36.46万 - 项目类别:
Continuing Grant
CAREER: Mechanisms and tradeoffs of dietary specialization in mammalian herbivores
职业:哺乳动物食草动物饮食专业化的机制和权衡
- 批准号:
0236402 - 财政年份:2003
- 资助金额:
$ 36.46万 - 项目类别:
Continuing Grant
Proposal for Conference on the History of Atmospheric CO2 and its Effect on the Evolution of Plants, Animals, and Ecosystems (Workshop held in Snowbird, Utah on December 6-8, 2001)
关于大气二氧化碳的历史及其对植物、动物和生态系统进化的影响会议的提案(研讨会于2001年12月6日至8日在犹他州斯诺伯德举行)
- 批准号:
0129299 - 财政年份:2001
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
Dietary Specialization in Mammals: Constraints and Costs of Detoxification of Plant Secondary Compounds
哺乳动物的饮食专门化:植物次生化合物解毒的限制和成本
- 批准号:
0079865 - 财政年份:2000
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
Dietary Specialization in Mammals: Tests of Detoxificaton and Elimination Models
哺乳动物的饮食专门化:解毒和消除模型的测试
- 批准号:
9809961 - 财政年份:1998
- 资助金额:
$ 36.46万 - 项目类别:
Standard Grant
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