Metals in Environmental and Biological Systems. A Rational Approach to Sample Pretreatment and Analysis

环境和生物系统中的金属。

• 批准号: 0821969
• 负责人: Purnendu Dasgupta
• 金额: $ 50万
• 依托单位: University of Texas at Arlington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821969&HistoricalAwards=false
• 关键词: Metals; Environmental; Biological; Systems.; Rational

The Analytical and Surface Chemistry Program in the Division of Chemistry supports the research groups of Professors Purnendu (Sandy) Dasgupta, Xiyun Guan, Subhrangsu Mandal, and Kevin Schug at the University of Texas - Arlington for collaborative research with scientists at the Northeastern University in Shenyang, China, to design, test, and implement field-portable and affordable metal detection systems involving novel nanopore sensing and charge detection technologies and unique metal-selective sample preparation techniques, utilizing room temperature ionic liquids and novel nanosorbents. The researchers use mass spectrometry techniques that they have developed for rapid characterization of binding of metals to other agents, including proteins. If cell-secreted specific metal binding agents are found, they will be used as gateways to otherwise nonspecific sensors. The derived ability to selectively detect and measure both harmful metals such as arsenic and essential nutrients such as zinc may have important applications in environmental, medical, and biochemical research. This international collaborative research project is supported jointly by NSF and the National Science Foundation of China. The study is also supported by the Office of International Science and Engineering (OISE) at NSF. Resulting instrumental advancements will be incorporated into teaching curricula. Cross-disciplinary training of engineering undergraduates, minority participation, and the annual participation of 4-5 competitively chosen high school students are an integral part of this project, designed to convey both the experience and the pleasure of carrying out meaningful frontline research and applying it to real samples in a useful manner.

化学系的分析和表面化学项目支持德克萨斯大学阿灵顿分校的Purnendu(Sandy)Dasgupta、Xi Yun Guan、Subhrangsu Mandal和Kevin Schug教授的研究团队与沈阳东北大学的科学家中国合作研究，设计、测试和实施现场便携且负担得起的金属检测系统，利用室温离子液体和新型纳米吸附材料，采用新型纳米孔传感和电荷检测技术以及独特的金属选择性样品制备技术。研究人员使用他们开发的质谱学技术来快速表征金属与包括蛋白质在内的其他试剂的结合。如果发现了细胞分泌的特定金属结合剂，它们将被用作通往其他非特异性传感器的网关。这种选择性地检测和测量有害金属(如砷)和必需营养素(如锌)的能力可能在环境、医学和生化研究中有重要的应用。这一国际合作研究项目得到了美国国家自然科学基金和中国国家科学基金的联合支持。这项研究也得到了美国国家科学基金会国际科学与工程办公室(OISE)的支持。由此产生的工具性进步将被纳入教学课程。工程本科生的跨学科培训，少数人参与，以及4-5名竞争性挑选的高中生每年的参与是该项目不可或缺的一部分，旨在传达开展有意义的一线研究并以有用的方式将其应用于实际样本的经验和乐趣。