Toxic Metals in the Northeast: From Biological To Environmental Implications

描述(由申请人提供) 超级基金有毒金属基础研究计划项目的总体目标是了解环境和人为来源的砷和汞暴露对人类健康的影响。该计划包括三个生物医学研究项目和两个非生物医学研究项目，两个科学支持核心，以及一个行政、研究翻译和培训核心。项目2(汉密尔顿)和项目8(斯坦顿)是分子毒理学项目，研究砷引起其不良健康影响的分子机制，分别侧重于内分泌干扰和膜蛋白运输和功能的破坏。项目7(Chen)是一个生态毒理学项目，研究汞如何在鱼中生物积累，项目9是一个植物生物学项目，重点是大米中砷的生物积累，每个项目都侧重于这些如何导致人类暴露在令人担忧的环境中。项目4(卡拉加斯)正在研究接触砷和汞对人类健康的影响，重点是新汉普郡孕妇通过食物(砷和汞)和井水(砷)接触这些毒物对后代的生殖和发育影响。核心B(杰克逊)是一个痕量元素分析核心，提供最先进的超低水平砷和汞的检测、定量和形态分析。CORE E(Moore)是一个综合生物学核心，它为项目提供全面的支持和整合从特定项目的分子生物学、基因组学、蛋白质组学、生物信息学、生物统计学和模型分析(每个核心都由达特茅斯的各个核心提供)的知识，以便更充分地理解、整合和将这些知识转化为利益相关者。调查人员研究翻译核心旨在通过帮助他们以最有效和适当的方式将适当的信息传达给每个利益相关者群体，有效地促进这一翻译。培训核心旨在利用他们高度跨学科和协作的计划，以促进对他们的学生进行最有效的培训。其目标是提供最好的科学，用于更有效的以科学为基础的风险评估，预测砷和汞暴露的具体病理生理后果，评估基因-环境、试剂-试剂和其他复杂的环境相互作用，评估处于高风险的特别敏感的亚群，并为这些暴露人群制定有效的干预措施。 行政核心(哈密尔顿) 描述(由申请人提供) 行政核心是达特茅斯超级基金基础研究计划(SBRP)的中心组织结构。它的主要作用是：1)提供基本的行政支持；2)代表达特茅斯大学和国立卫生研究院为达特茅斯SBRP项目提供会计支持、授予前和授予后的支持以及财务监督；3)促进信息传播，并作为一个中心联络点和沟通资源；4)作为政府与NIEHS、EPA和其他联邦、州和地方机构的联络人，以便向这些机构和其他适当的利益攸关方进行有效的沟通和技术转让；5)与大学的相关部门合作，协调并为培训中心的教育和培训活动提供行政支持；6)协调并为计划规划和监督活动提供行政支持，包括与计划的各种正式和非正式研究、教育和翻译相关的会议；以及，7)协调并为正式翻译核心和非正式翻译活动提供行政支持；必要时协助其他行政和沟通活动。该办公室将配备一名行政/财务助理和一名办公室/财务经理，他们将兼职为该方案工作，并兼职为环境健康科学中心及其其他研究、教育和翻译方案工作；一名兼职翻译协调员、一名兼职科学作家和一名兼职翻译助理；以及该方案的主任和副主任。专业人员与主任和副主任一起，通过行政核心工作，为计划提供凝聚力的结构和整合。行政核心的实体办公室还包括所有行政职能，包括培训和翻译核心的行政活动，并作为所有方案成员和与方案互动的人员的中心联络点。

DESCRIPTION (provided by applicant) The overall objective of this Superfund Basic Research Program Project on toxic metals is to understand the human health impact of exposure to arsenic and mercury from environmental and anthropogenic sources. This program consists of three biomedical and two non-biomedical research projects, two scientific support cores, and an Administrative, Research Translation and Training Core. Projects 2 (Hamilton) and 8 (Stanton) are molecular toxicology projects investigating the molecular mechanisms by which arsenic elicits its adverse health effects, focusing on endocrine disruption and disruption of membrane protein trafficking and function, respectively. Project 7 (Chen) is an ecotoxicology project examining how mercury bioaccumulates in fish, and Project 9 is a plant biology project focusing on bioaccumulation of arsenic in rice, each focusing on how these lead to human exposures of concern. Project 4 (Karagas) is examining the human health effects of exposure to arsenic and mercury, focusing on reproductive and developmental effects in offspring of pregnant women in New Hampshire who are exposed to these toxicants via their food (arsenic and mercury) and well water (arsenic). Core B (Jackson) is a Trace Elements Analysis Core that provides state-of-the-art ultra-low level detection, quantitation and speciation of arsenic and mercury. Core E (Moore) is an Integrative Biology Core that provides comprehensive support and integration of knowledge from the project-specific molecular biology, genomics, proteomics, bioinformatics, biostatistics and modeling analysis (each provided by individual cores at Dartmouth) to the program in order to more fully understand, integrate and translate this knowledge to stakeholders. The investigators' Research Translation Core is designed to effectively facilitate this translation by assisting them in communicating the proper information in the most effective and appropriate way to each stakeholder group. The Training Core is designed to exploit their highly interdisciplinary and collaborative program in order to foster the most effective training of their students. The goal is to provide the very best science that can be used for more effective science-based risk assessments, for predicting the specific patho-physiological consequences of arsenic and mercury exposure, for assessing gene-environment, agent-agent and other complex environmental interactions, for assessing specifically sensitive sub-populations at elevated risk, and for developing effective interventions for these exposed populations. ADMINISTRATIVE CORE (Hamilton) Description (provided by applicant) The Administrative Core serves as the central organizing structure for the Dartmouth Superfund Basic Research Program (SBRP). Its primary roles are to: 1) provide basic administrative support; 2) provide accounting support, pre- and post-award support, and financial oversight for the Dartmouth SBRP Program on behalf of the University and the NIH; 3) facilitate information dissemination, and serve as a central point of contact and as a communication resource; 4) serve as government liaison with the NIEHS, the EPA and other federal, state and local agencies for the purposes of effective communication and technology transfer to these agencies and other appropriate stakeholders; 5) coordinate and provide administrative support for the education and training activities of the Training Core, in collaboration with the relevant departments of the University; 6) coordinate and provide administrative support for program planning and oversight activities including the various formal and informal research, education and translation related meetings of the program; and, 7) coordinate and provide administrative support for formal Translation Core and informal translation activities; and assist in other administrative and communications activities as necessary. This office will be staffed by an Administrative/ Financial Assistant and an Office/Financial Manager who work part-time in their respective roles for this program and part-time for the Center for Environmental Health Sciences and its other research, education and translation programs; a part-time Translation Coordinator, a part-time Science Writer and a part-time Translation Assistant; and, the Director and Associate Directors of the program. The professional staff, in conjunction with the Director and Associate Directors, works through the Administrative Core to provide the cohesive structure and integration to the program. The physical offices of the Administrative Core also house all administrative functions including the administrative activities of the Training and Translation Cores, and serve as a central point of contact for all program members and those with whom the program interacts.