GOALI: A Miniature Ion Chromatograph and Chromatography Imaging

在这个由化学部化学测量和成像项目资助的项目中，德克萨斯大学阿灵顿分校的Purnendu Dasgupta教授和学生正在开发新一代可在现场使用的小型便携式分析仪。该项目利用NSF的学术界与工业界联络的资助机会（GOALI）计划与领先的离子色谱（IC）制造商Thermo Fisher Dionex（桑尼维尔，加利福尼亚州）形成行业联盟。几名学生将有机会在制造商的设施实习，行业科学家将共同监督学生建造微型，现场便携式离子色谱仪的低占地面积和低功耗。更广泛的影响是通过开发一个现场部署的仪器，将在许多应用中使用，并通过本科生和研究生的教育和培训，包括独特的和广泛的工业互动。该项目有两个独立的广泛目标：虽然目前大多数阴离子分析都是通过离子色谱法进行的，但该设备仍然太重，耗电量太大，无法在现场轻松部署。本计画旨在开发一种小型、可携式、低耗电量的离子层析仪，以供野外使用。而不是填充柱，抑制开放式管状（OT）IC被设想，其中柱将包含完整的抑制器和导纳检测器，用于全功能的梯度能力，抑制IC。此外，将存在第二导纳检测器。在该检测器之前，碱将渗透通过壁并与第一检测器流出物混合;已知该原理能够检测非常弱的酸性阴离子，这在目前是不可能的。第二个目标是探索液相和离子色谱中的扫描检测，使用各种检测器和分离模式。玻璃、二氧化硅和聚合物柱对几种类型的检测器是透明的。扫描平台提供了一种廉价的高分辨率手段，可以在分离发生时观察色谱柱内发生的分离。最终结果是，人们可以在真实的时间内观察分离，并且原则上为洗脱液组成提供自动反馈以改进分离。在多次扫描过程中产生的丰富数据将在完全分离发生之前实现准确的定量。扫描检测可显示未检测到的内容，并提供色谱柱运行状况的诊断。最后，在梯度洗脱中，预期分析物的时间位置和速度的三维图提供本质上是色谱的并且不依赖于检测器的识别标记。

In this project funded by the Chemical Measurement and Imaging program of the Chemistry Division, Professor Purnendu Dasgupta and students at the University of Texas at Arlington are developing a new generation of small portable analyzers that can be used in the field. This project uses the Grant Opportunities for Academic Liaison with Industry (GOALI) program of the NSF to form an industry alliance with a leading ion chromatography (IC) manufacturer, Thermo Fisher Dionex (Sunnyvale, CA). Several students will have an opportunity to intern at the manufacturer's facility and industry scientists will co-supervise students towards a building miniature, field-portable ion chromatographs of low footprint and low power. The broader impacts are addressed through the development of a field deployable instrument that will be used in many applications, and through undergraduate and graduate student education and training that includes unique and extensive industrial interactions. This project has two separate broad goals: While most anion analyses today are carried out by ion chromatography, the equipment is still too heavy and consumes too much power to be easily deployed in the field. This project seeks to develop a small, portable, low power consumption ion chromatograph instrument for field deployment. Rather than packed columns, a suppressed open tubular (OT) IC is envisioned where the column will contain an integral suppressor and admittance detector for fully functional gradient-capable, suppressed IC. Further, a second admittance detector will be present. Before this detector, a base will permeate through the wall and mix with the first detector effluent; this principle is known to enable detection of very weak acid anions, not presently possible. The second goal is to explore scanning detection in liquid and ion chromatography, using a variety of detectors and separation modes. Glass, silica and polymer columns are transparent to several types of detectors. A scanning platform provides an inexpensive high-resolution means to look at separations occurring inside columns as they occur. The net result is that one can look at separations in real time and, in principle, provide automated feedback to eluent composition to improve separations. The wealth of data generated during multiple scans will enable accurate quantification actually before complete separation occurs. Scanning detection visualizes what did not elute and provides a diagnostic of column health. Finally, in gradient elution, the three dimensional map of time location and speed of an analyte is expected to provide an identification marker that is intrinsically chromatographic and not detector-dependent.