Toxic Metals in the Northeast: From Biological To Environmental Implications

东北地区的有毒金属:从生物到环境的影响

基本信息

  • 批准号:
    8056111
  • 负责人:
  • 金额:
    $ 277.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-04-01 至 2013-03-31
  • 项目状态:
    已结题

项目摘要

The overall objective of this Superfund Basic Research Program Project on toxic metals is to understand the human health impact of exposure to arsenic and mercury from environmental and anthropogenic sources. This program consists of three biomedical and two non-biomedical research projects, two scientific support cores, and an Administrative, Research Translation and Training Core. Projects 2 (Hamilton) and 8 (Stanton) are molecular toxicology projects investigating the molecular mechanisms by which arsenic elicits its adverse health effects, focusing on endocrine disruption and disruption of membrane protein trafficking and function, respectively. Project 7 (Chen) is an ecotoxicology project examining how mercury bioaccumulates in fish, and Project 9 is a plant biology project focusing on bioaccumulation of arsenic in rice, each focusing on how these lead to human exposures of concern. Project 4 (Karagas) is examining the human health effects of exposure to arsenic and mercury, focusing on reproductive and developmental effects in offspring of pregnant women in New Hampshire who are exposed to these toxicants via their food (arsenic and mercury) and well water (arsenic). Core B (Jackson) is a Trace Elements Analysis Core that provides state-of-the-art ultra-low level detection, quantitation and speciation of arsenic and mercury. Core E (Moore) is an Integrative Biology Core that provides comprehensive support and integration of knowledge from the project-specific molecular biology, genomics, proteomics, bioinformatics, biostatistics and modeling analysis (each provided by individual cores at Dartmouth) to the program in order to more fully understand, integrate and translate this knowledge to stakeholders. The investigators' Research Translation Core is designed to effectively facilitate this translation by assisting them in communicating the proper information in the most effective and appropriate way to each stakeholder group. The Training Core is designed to exploit their highly interdisciplinary and collaborative program in order to foster the most effective training of their students. The goal is to provide the very best science that can be used for more effective science-based risk assessments, for predicting the specific patho-physiological consequences of arsenic and mercury exposure, for assessing gene-environment, agent-agent and other complex environmental interactions, for assessing specifically sensitive sub-populations at elevated risk, and for developing effective interventions for these exposed populations.
这项关于有毒金属的超级基金基础研究计划项目的总体目标是了解环境和人为来源的砷和汞对人类健康的影响。该计划包括三个生物医学和两个非生物医学研究项目,两个科学支持核心,以及一个行政,研究翻译和培训核心。项目2(汉密尔顿)和项目8(斯坦顿)是分子毒理学项目,研究砷引起其不良健康影响的分子机制,分别重点关注内分泌干扰和膜蛋白运输和功能的干扰。项目7(Chen)是一个生态毒理学项目,研究汞如何在鱼类中生物累积,项目9是一个植物生物学项目,重点是砷在大米中的生物累积,每个项目都侧重于这些如何导致人类接触令人关切的问题。项目4(Karagas)正在研究接触砷和汞对人类健康的影响,重点是新罕布什尔州孕妇通过食物(砷和汞)和井水(砷)接触这些有毒物质对后代生殖和发育的影响。岩芯B(杰克逊)是一种微量元素分析岩芯,可提供最先进的超低水平砷和汞的检测、定量和形态分析。核心E(摩尔)是一个综合生物学核心,提供全面的支持和知识整合,从项目特定的分子生物学,基因组学,蛋白质组学,生物信息学,生物统计学和建模分析(每个由达特茅斯的个别核心提供)到程序,以便更充分地理解,整合和翻译这些知识的利益相关者。 研究人员的研究翻译核心旨在通过帮助他们以最有效和最适当的方式向每个利益相关者群体传达适当的信息来有效地促进这种翻译。培训核心旨在利用他们的高度跨学科和协作计划,以促进学生的最有效的培训。目标是提供最好的科学,用于更有效的基于科学的风险评估,预测砷和汞暴露的具体病理生理后果,评估基因-环境、物剂-物剂和其他复杂的环境相互作用,评估风险升高的特别敏感的亚群体,并为这些接触人群制定有效的干预措施。

项目成果

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Bruce A. Stanton其他文献

New insights into cystic fibrosis: molecular switches that regulate CFTR
囊性纤维化的新见解:调节 CFTR 的分子开关
  • DOI:
    10.1038/nrm1949
  • 发表时间:
    2006-06-01
  • 期刊:
  • 影响因子:
    90.200
  • 作者:
    William B. Guggino;Bruce A. Stanton
  • 通讯作者:
    Bruce A. Stanton
Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct.
大鼠内髓集合管顶膜和基底外侧膜电导的表征。
Lung-kidney axis in cystic fibrosis: Early urinary markers of kidney injury correlate with neutrophil activation and worse lung function
囊性纤维化中的肺-肾轴:肾脏损伤的早期尿液标志物与中性粒细胞活化和更差的肺功能相关
  • DOI:
    10.1016/j.jcf.2024.12.007
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    6.000
  • 作者:
    Grace M. Rosner;Himanshu B. Goswami;Katherine Sessions;Lindsay K. Mendyka;Brenna Kerin;Irma Vlasac;Diane Mellinger;Lorraine Gwilt;Thomas H. Hampton;Martha Graber;Alix Ashare;William T. Harris;Brock Christensen;Bruce A. Stanton;Agnieszka Swiatecka-Urban;Sladjana Skopelja-Gardner
  • 通讯作者:
    Sladjana Skopelja-Gardner

Bruce A. Stanton的其他文献

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{{ truncateString('Bruce A. Stanton', 18)}}的其他基金

Let-7b in Extracellular Vesicles Secreted by Bronchial Epithelial Cells Increases the Antibiotic Sensitivity of Pseudomonas
支气管上皮细胞分泌的胞外囊泡中的 Let-7b 增加假单胞菌的抗生素敏感性
  • 批准号:
    10319005
  • 财政年份:
    2020
  • 资助金额:
    $ 277.92万
  • 项目类别:
Let-7b in Extracellular Vesicles Secreted by Bronchial Epithelial Cells Increases the Antibiotic Sensitivity of Pseudomonas
支气管上皮细胞分泌的胞外囊泡中的 Let-7b 增加假单胞菌的抗生素敏感性
  • 批准号:
    10525239
  • 财政年份:
    2020
  • 资助金额:
    $ 277.92万
  • 项目类别:
Retrieval, Reprocessing, Normalization and Sharing of Gene Expression and Lung Microbiome Data Sets to Facilitate AI/ML Analysis Studies of Bacterial Lung Infections
基因表达和肺部微生物组数据集的检索、再处理、标准化和共享,以促进细菌肺部感染的 AI/ML 分析研究
  • 批准号:
    10594180
  • 财政年份:
    2020
  • 资助金额:
    $ 277.92万
  • 项目类别:
Gastrointestinal Biology Core
胃肠生物学核心
  • 批准号:
    10001761
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
CF Bioinformatics and Biostatistics Core
CF 生物信息学和生物统计学核心
  • 批准号:
    10001763
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
Gastrointestinal Biology Core
胃肠生物学核心
  • 批准号:
    10686312
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
CF Bioinformatics and Biostatistics Core
CF 生物信息学和生物统计学核心
  • 批准号:
    10686327
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
Gastrointestinal Biology Core
胃肠生物学核心
  • 批准号:
    10241580
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
CF Bioinformatics and Biostatistics Core
CF 生物信息学和生物统计学核心
  • 批准号:
    10241582
  • 财政年份:
    2018
  • 资助金额:
    $ 277.92万
  • 项目类别:
Arsenic and Innate Immunity in Human Lung
砷与人肺的先天免疫
  • 批准号:
    8881879
  • 财政年份:
    2014
  • 资助金额:
    $ 277.92万
  • 项目类别:

相似国自然基金

Rare Metals(稀有金属(英文版))
  • 批准号:
    51224002
  • 批准年份:
    2012
  • 资助金额:
    20.0 万元
  • 项目类别:
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相似海外基金

Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    7916292
  • 财政年份:
    2009
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Envir*
东北地区的有毒金属:从生物到环境*
  • 批准号:
    7067113
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    8671914
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    8249958
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    7845291
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    8213067
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Envir*
东北地区的有毒金属:从生物到环境*
  • 批准号:
    7218715
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    7608678
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Envir*
东北地区的有毒金属:从生物到环境*
  • 批准号:
    7459218
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
Toxic Metals in the Northeast: From Biological To Environmental Implications
东北地区的有毒金属:从生物到环境的影响
  • 批准号:
    8701620
  • 财政年份:
    1997
  • 资助金额:
    $ 277.92万
  • 项目类别:
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