Multifunctional Biomedical Nanosensors Based on Single Nanocomposite Nanowires

基于单纳米复合纳米线的多功能生物医学纳米传感器

• 批准号: 0824035
• 负责人: Minhee Yun
• 金额: $ 26.33万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0824035&HistoricalAwards=false
• 关键词: Multifunctional; Biomedical; Nanosensors; Based; Single

ABSTRACTThe objective of this proposal is to develop multifunctional nanosensors for biomedical applications based on single nanocomposite nanowires (NWs) (nanomaterial-embedded single-conducting polymer NWs). The approach is to build highly efficient biomarker sensors using electrochemically grown NWs that are easily constructed and reproducible because of the unique nature of the proposed NW fabrication with process controllability and site-specific method. Intellectual Merit: NW sensor technology will be developed using single nanocomposite NWs in the proposed work. In order to demonstrate a single nanocomposite NW biomedical sensor, a cardiac sensor is selected to detect myoglobin, one of the very commonly used biomarkers for cardiovascular diseases (CVD). During the proposed work, the relationship between single NW lengths and diameters will be studied both theoretically and experimentally for optimizing sensor performances. The proposed research will provide information about the coupling effects of conducting polymers with carbon nanotubes or nanoparticles in addition to the properties of the individual components with synergistic effects such as mechanical stability, easy fabrication, and conductivity controllability.Broader Impact: The proposed research will find applications of nanocomposite NWs for biomedical industries, which will benefit our society and advance future technology. The proposed single nanocomposite NW technique could lead to the possibility of diagnosing biomarkers that cannot be diagnosed with conventional technology. For educational efforts, participation in an existing outreach program such as Pittsburgh Junior Academy of Science (PJAS) in connection with course development will be incorporated.

摘要本研究的目的是基于单纳米复合纳米线（nanomateral-embedded single-conducting polymer NWs）开发生物医学应用的多功能纳米传感器。该方法是建立高效的生物标记物传感器，使用电化学生长的纳米线，很容易构建和再现，因为所提出的纳米线制造的独特性质与过程的可控性和特定地点的方法。智力优势：NW传感器技术将在拟议的工作中使用单一的纳米复合材料NW开发。为了展示单个纳米复合NW生物医学传感器，选择心脏传感器来检测肌红蛋白，肌红蛋白是心血管疾病（CVD）非常常用的生物标志物之一。在拟议的工作中，单NW长度和直径之间的关系将在理论和实验上进行研究，以优化传感器的性能。该研究将提供有关导电聚合物与碳纳米管或纳米颗粒的耦合效应的信息，以及具有协同效应的单个组分的性能，如机械稳定性，易于制造和导电可控性。更广泛的影响：该研究将发现纳米复合材料纳米线在生物医学行业的应用，这将造福我们的社会，并推动未来的技术。提出的单一纳米复合NW技术可能导致诊断生物标志物的可能性，而这些生物标志物无法用传统技术诊断。对于教育工作，参与现有的推广计划，如匹兹堡少年科学院（PJAS）与课程开发将被纳入。