Gold Nanoparticle Ensembles on Optical Plasmon Capillaries for Virus/DNA Sensing

本研究的目的是利用光与纳米颗粒结构阵列上的自由电子相互作用来检测和区分硅毛细管内的病毒血清型。 阵列是由“自下而上”的方法形成的，以提供独特的光谱灵敏度和热传播。 利用麦克斯韦方程组的新解和一种新的量热计，将对阵列进行调整，以控制光-电子相互作用，从而在？T10飞摩尔（fM）在？T10分钟使用？T10 mW。 这项研究有望开发出快速、廉价的病毒/DNA传感器，以取代现有的免疫测定或基因分型方法，这些方法速度慢、不敏感且资本密集。它的技术影响来自于光-电子相互作用的应用，以开发光子电路，高密度磁光数据存储，近场光学显微镜和太赫兹imaging.This investigation will educate two underrepresentative students in active nanostructures and biophotonics in a campus wide initiative to manufacture and analyze nano-scale devices and materials. 其社会影响包括让本科生在为社区大学和高中学生准备的课堂动手教学模块和动手实验室体验中展示传感器，这是由PI共同发起的为期5年的NSF赞助合作的一部分，旨在使STEM课程中代表性不足的学生的入学率和保留率提高一倍。

This study is aimed at detecting and distinguishing virus serotypes inside silicon capillaries using light interacting with free electrons on structured arrays of nanoparticles. Arrays are formed by a ¡¥bottom-up¡¦ method to provide unique spectral sensitivity and heat dissemination. Arrays will be tuned to control light-electron interactions using new solution to Maxwell¡¦s Equations and a novel calorimeter to detect viral DNA at ?T10 femtomolar (fM) in ?T10 minutes using ?T10 mW. The proposed research is expected to develop rapid, inexpensive, virus/DNA sensors to replace existing immunoassays or genotyping methods that are slow, insensitive and capital-intensive. Its technical impact arises from applications of light-electron interactions to develop photonic circuits, high-density magneto-optic data storage, near-field optical microscopy, and terahertz imaging.This investigation will educate two underrepresented graduate students in active nanostructures and biophotonics in a campus-wide initiative to fabricate and analyze nano-scale devices and materials. Its social impact includes having undergraduates demonstrate sensors in hands-on instructional modules prepared for classroom and hands-on lab experiences for community-college and high-school students as part of a 5-year NSF-sponsored collaboration co-initiated by the PI to double enrollment and retention of students underrepresented in STEM courses.