Microstructural Evolution of Molecular Crystals
分子晶体的微观结构演化
基本信息
- 批准号:0825994
- 负责人:
- 金额:$ 26.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-01 至 2012-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research objective of this award is to developrobust numerical methods in coordination with experiments to predict the mechanical response of molecular crystal particles at the micron and submicron scales.In pharmaceutical and food industries,this type ofmaterialis subjected to mechanical milling during manufacturing to reduce particle size. During this processmechanical stresses produce structural changes in the crystal latticethatoften affect key properties of drug products, such as stability and dissolution rates.The theory and experiments proposed in this project will provide information about the interaction of crystalline defects with surfaces due to the high surface to volume ratio in microscopic particles and will be a step toward the integration of microscopic mechanisms in the numerical modeling of crystalline materials in general.The proposed research involves the following tasks, (1) Experimental approach to detect disorder in milled materials using physical and chemical analytical characterization techniques including spectroscopy, thermal, and surface methods to better understand and control defects and interactions (2) Mechanical testing (3) Numerical simulations of deformation of particles under mechanical loading. This project will make important contributions towardsthe understanding of the evolution of molecular crystals during food and drug processing. If successful, the proposed numerical and experimental effort will have an impact in the development of materials less sensitive to detrimental changes during milling processingas well as in the optimization of operational formulations and quality control in food and pharmaceutical industries.The results of this work will be integrated into the undergraduate and graduate curriculum in Engineering and Pharmaceutical Sciences at Purdue and therefore, will influence the formation of new generations of engineers and pharmaceutical scientistswith a multidisciplinary formation and with the ability to successfully work in collaborative programs.
该奖项的研究目标是发展与实验相结合的数值方法,以预测分子晶体颗粒在微米和亚微米尺度上的机械响应。在制药和食品工业中,这类材料在制造过程中会受到机械研磨以减小颗粒尺寸。在此过程中,机械应力会在晶格中产生结构变化,这通常会影响药物产品的关键特性,如稳定性和溶解速率。该项目提出的理论和实验将提供有关晶体缺陷与表面相互作用的信息,由于微观颗粒中的高表面积与体积比,并将朝着在数值模拟中整合微观机制迈出一步。提出的研究涉及以下任务,(1)使用物理和化学分析表征技术(包括光谱学,热学和表面方法)检测研磨材料中的无序的实验方法,以更好地理解和控制缺陷和相互作用(2)机械测试(3)机械载荷下颗粒变形的数值模拟。该项目将对理解食品和药物加工过程中分子晶体的演变做出重要贡献。如果成功的话,所提出的数值和实验工作将对材料的发展产生影响,这些材料对研磨加工过程中的有害变化不敏感,以及对食品和制药行业的操作配方和质量控制进行优化。这项工作的结果将被整合到普渡大学工程和制药科学的本科和研究生课程中,因此,将影响新一代工程师和制药科学家的形成,具有多学科的形成和成功合作项目的能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marisol Koslowski其他文献
Hot-spots in polycrystalline math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si52.svg" display="inline" id="d1e1600" class="math"miβ/mi/math-tetramethylene tetranitramine (math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si52.svg" display="inline" id="d1e1606" class="math"miβ/mi/math-HMX): The role of plasticity and friction
多晶数学中的热点:可塑性和摩擦的作用
- DOI:
10.1016/j.jmps.2022.105157 - 发表时间:
2023-02-01 - 期刊:
- 影响因子:6.000
- 作者:
Camilo A. Duarte;Marisol Koslowski - 通讯作者:
Marisol Koslowski
Grain refinement in metal microparticles subjected to high impact velocities
金属微粒在高冲击速度下的晶粒细化
- DOI:
10.1016/j.jmps.2024.106009 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:6.000
- 作者:
Chongxi Yuan;Marisol Koslowski - 通讯作者:
Marisol Koslowski
Phase field dislocation dynamics modeling of shearing modes in Ni<sub>2</sub>(Cr,Mo,W)-containing HAYNES® 244® Superalloy
- DOI:
10.1016/j.actamat.2024.120453 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Thomas Mann;Michael G. Fahrmann;Marisol Koslowski;Michael S. Titus - 通讯作者:
Michael S. Titus
Effect of Sn Orientation on Electromigration Failure in CuSn Solders
- DOI:
10.1007/s11664-024-11301-8 - 发表时间:
2024-07-26 - 期刊:
- 影响因子:2.500
- 作者:
Andrew Minh Pham;Fariha Haq;Subramanya Sadasiva;Guangxu Li;Marisol Koslowski - 通讯作者:
Marisol Koslowski
Marisol Koslowski的其他文献
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{{ truncateString('Marisol Koslowski', 18)}}的其他基金
Controlling Heterogeneous Stress Relaxation in Tin Films: Whiskers, Grain Boundary Sliding, and Beyond
控制锡膜中的非均匀应力松弛:晶须、晶界滑动等
- 批准号:
1610420 - 财政年份:2016
- 资助金额:
$ 26.39万 - 项目类别:
Standard Grant
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