Collaborative Research: Biologically Inspired Robotic Microswimmers

合作研究：仿生机器人微型游泳者

• 批准号: 0828167
• 负责人: MinJun Kim
• 金额: $ 24.78万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0828167&HistoricalAwards=false
• 关键词: Collaborative; Research; Biologically; Inspired; Robotic

CBET-0828167KimBacterial flagellar propulsion represents an extraordinary system in nature for generating motion at the micrometer scale due to their unique molecular polymeric structure adapting to different shapes, depending on the local chemical and flow conditions. Their motion induces a local flow that can be used to propel cells as well as much larger structures through a fluid environment. This collaborative research team plans to understand, to model and to exploit the physics of flagellar propulsion for use in engineered microfluidic systems. The objective of the program is to understand the fundamental scientific principles that govern the assembly and operation of flagella-propelled devices (both single swimmers and collectively-powered devices), as well as to demonstrate the enabling technologies necessary to harness polymeric protein nanostructures such as bacterial flagellar filaments on microstructures for use in micron-scale engineered propulsion systems. This collaborative proposal between Drexel University and Brown University is the first to focus on the specific characteristics associated with the polymorphic transformation of bacterial flagellar filaments to demonstrate the ability to move larger engineered elements through a microfluidic landscape in a controlled and directed manner. Fundamental scientific merits addressed by this proposal include using nanoscale flagellar filaments in engineered systems for micron-scale propulsion. Basic questions are to be answered regarding the mechanisms leading to self-coordination of flagellar filaments in responses to a variety of external stimuli. Possible coordination of flagellar filaments to transport microstructures in various microfluidic environments will be examined, thus enabling an entirely new class of swimming robotic systems with applications to bio-engineered actuators, drug delivery systems, and machines for micron-scale transport and assembly. Demonstration of the control of bacterial flagellar filaments at micro- and nanoscales and the ability to integration information technology with bio and nanotechnology will have great impact. The program will have an intensive outreach component, including active recruitment and training of women and underrepresented minorities engineers. The program will leverage and expand existing and proven programs already in place at Brown and Drexel. The PIs will additionally conduct outreach to inner-city high school student and teacher populations in both Providence and Philadelphia through the BROWNOUT (Brown) and INSPIRE (Drexel) programs.

CBET-0828167Kim 细菌鞭毛推进代表了自然界中一种非凡的系统，可以产生微米级的运动，因为它们独特的分子聚合结构可以根据当地的化学和流动条件适应不同的形状。它们的运动引起局部​​流动，可用于推动细胞以及更大的结构通过流体环境。该合作研究团队计划了解、建模和利用鞭毛推进的物理原理，以用于工程微流体系统。该计划的目标是了解控制鞭毛推进装置（包括单个游泳者和集体供电装置）组装和操作的基本科学原理，并展示利用聚合物蛋白纳米结构（例如微结构上的细菌鞭毛丝）所需的使能技术，用于微米级工程推进系统。德雷塞尔大学和布朗大学之间的这项合作提案首次关注与细菌鞭毛丝多态性转化相关的具体特征，以证明以受控和定向方式通过微流体景观移动更大的工程元件的能力。该提案提出的基本科学价值包括在工程系统中使用纳米级鞭毛丝进行微米级推进。需要回答有关鞭毛丝自我协调以响应各种外部刺激的机制的基本问题。 将检查鞭毛丝在各种微流体环境中运输微结构的可能性，从而实现全新类型的游泳机器人系统，并应用于生物工程执行器、药物输送系统以及微米级运输和组装机器。在微米和纳米尺度上控制细菌鞭毛丝以及将信息技术与生物和纳米技术相结合的能力的示范将产生巨大的影响。该计划将包含密集的外展部分，包括积极招募和培训女性和代表性不足的少数族裔工程师。 该计划将利用和扩展布朗大学和德雷克塞尔大学现有的和经过验证的计划。 此外，PI 还将通过 BROWNOUT（布朗）和 INSPIRE（德雷克塞尔）计划向普罗维登斯和费城的市中心高中学生和教师群体进行推广。