MRI: Acquisition of an Integrated Bionanomaterials Characterization and Imaging System for Research and Education Initiatives in Bioengineering

MRI：获取集成生物纳米材料表征和成像系统，用于生物工程研究和教育计划

• 批准号: 1827831
• 负责人: MinJun Kim
• 金额: $ 35.17万
• 依托单位: Southern Methodist University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827831&HistoricalAwards=false
• 关键词: MRI; Acquisition; Integrated; Bionanomaterials; Characterization

This award is to purchase a bio/nanomaterials characterization and imaging system, which will be used by seven North Texas academic research institutions. The proposed instrument offers multi-functional capabilities by integrating a confocal laser scanning microscope (CLSM), atomic force microscope (AFM), and digital light processing (DLP). This new system will enable 20 research groups to perform material imaging, manipulation, and property measurements of synthetic and biological nano/microstructures with optical, electrical, mechanical, and thermal stimulations in both ambient air and liquid environments. The equipment will be housed at the Biological, Actuation, Sensing, and Transport Laboratory on Southern Methodist University campus, a centralized location in the Dallas-Fort Worth Metroplex. Graduate and undergraduate students will be trained in this state-of-the-art facility, allowing students to build a rich foundation for studying biological cells and organic/inorganic nano/microstructures. The proposed imaging instrument will benefit a number of ongoing research projects. The DLP system will provide fully controllable patterns of light, where the CLSM-AFM system will improve the capability of property measurement of biological and synthetic materials. The use of the CLSM-AFM-DLP will broaden the capability of research in molecular dynamics, bacterial swarms, flagellar mechanics, biologically-inspired robotics, determination of dielectric and mechanical properties of biological cells and materials, laser-assisted micro/nanofabrication, and imaging reactive oxygen, nitrogen and sulfur species. This instrument can lead to important findings for nature-inspired technology and enable future research in various areas: 1) advanced imaging and property measurement of organic/inorganic nano/microstructures, 2) spatial light modulated techniques for live cell imaging, 3) thermal transport and wettability of some low energy surfaces at the liquid-solid interface, and 4) electrical investigation of bio-templated advanced nanostructures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是购买生物/纳米材料的特征和成像系统，该系统将由北德克萨斯州七家学术研究机构使用。提出的仪器通过整合共聚焦激光扫描显微镜（CLSM），原子力显微镜（AFM）和数字光处理（DLP）来提供多功能功能。这个新系统将使20个研究组能够在环境空气和液体环境中使用光学，电气，机械和热刺激进行合成和生物纳米/微结构的合成和生物纳米/微观结构的材料成像。该设备将安置在南方卫理公会大学校园的生物学，驱动，传感和运输实验室，该实验室是达拉斯 - 沃思 - 沃思 - 沃思·Metroplex的集中地点。研究生和本科生将在此最先进的设施中接受培训，使学生能够为研究生物细胞和有机/无机纳米/微观结构建立丰富的基础。拟议的成像工具将使许多正在进行的研究项目受益。 DLP系统将提供完全可控制的光模式，其中CLSM-AFM系统将提高生物和合成材料的性质测量能力。 CLSM-AFM-DLP的使用将扩大分子动力学，细菌群，鞭毛力学，生物启发的机器人技术的能力，确定生物细胞和材料的介电和力学性能，激光辅助的微型微/含量/含量/含量/含量的氧化和想象中的反应性氧气和硫酸盐，二和二。 This instrument can lead to important findings for nature-inspired technology and enable future research in various areas: 1) advanced imaging and property measurement of organic/inorganic nano/microstructures, 2) spatial light modulated techniques for live cell imaging, 3) thermal transport and wettability of some low energy surfaces at the liquid-solid interface, and 4) electrical investigation of bio-templated advanced nanostructures.This award反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准来评估值得支持。