Signaling Vector Analysis of Cell Migration

CBET-0828936 Jason M Haugh，北卡罗来纳州州立大学智力价值该项目为在细胞内信号转导水平上思考成纤维细胞迁移的控制提供了一个新的概念框架，并为定量分析它提供了新的工具。如果成功，拟议的工作将更普遍地统一不同的细胞迁移刺激和行为，为其他细胞类型、环境背景和潜在信号转导网络的分子水平扰动的更雄心勃勃的研究提供蓝图。更广泛的影响该项目将有助于培养工程分析、细胞生物学、荧光显微镜、图像分析和动力学建模等跨学科领域的研究人员。在所有这些努力中，PI将保持一个包容性的研究环境，在各个层面上拥抱多样性。拟议研究的结果将发表在存档的同行评审期刊上，所有MATLAB代码将通过PI的网站免费提供。

CBET-0828936Jason M Haugh, North Carolina State UniversityIntellectual merit This project offers a new conceptual framework for thinking about control of fibroblast migration at the level of intracellular signal transduction and novel tools for quantitatively analyzing it. If successful, the proposed work would more generally unify distinct cell migration stimuli and behaviors in terms of common signaling dynamics, providing a blueprint for more ambitious studies with other cell types, environmental contexts, and molecular-level perturbations of the underlying signal transduction network.Broader impacts The project would contribute to the training of researchers in the cross-disciplinary areas of engineering analysis, cell biology, fluorescence microscopy, image analysis, and kinetic modeling. In all of these endeavors, the PI will maintain an inclusive research environment that embraces diversity on all levels. The results of the proposed research will be published in archived, peer reviewed journals, and all MATLAB codes will be freely available via the PI's website.