Engineering Intracellular Signal Transduction Networks: Life and Death Decisions at the Molecular Level

最终目标是建立一个数学模型，捕捉细胞增殖和细胞死亡信号通路之间的串扰。建议的工作重点是Ras/Raf和P13K/Akt通路。将收集初步数据，调查和说明这些通路之间的串扰。有了改进的理解和掌握的数学描述，可以设想用于优化细胞培养或开发药物化合物的改进的基础。

The ultimate goal is to build a mathematical model that captures the cross-talk between cell proliferation and cell death signaling pathways. The focus of the proposed work is on the Ras/Raf and P13K/Akt pathways. Preliminary data will be gathered that investigates and illustrates the cross-talk between these pathways. With an improved understanding and a mathematical description in-hand, an improved base for optimizing cell culture or developing pharmaceutical compounds can be envisioned.