Engineering Intracellular Signal Transduction Networks: Life and Death Decisions at the Molecular Level

工程细胞内信号转导网络：分子水平的生死决定

• 批准号: 0111434
• 负责人: Jason Haugh
• 金额: $ 10万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111434&HistoricalAwards=false
• 关键词: Engineering; Intracellular; Signal; Transduction; Networks

The ultimate goal is to build a mathematical model that captures the cross-talk between cell proliferation and cell death signaling pathways. The focus of the proposed work is on the Ras/Raf and P13K/Akt pathways. Preliminary data will be gathered that investigates and illustrates the cross-talk between these pathways. With an improved understanding and a mathematical description in-hand, an improved base for optimizing cell culture or developing pharmaceutical compounds can be envisioned.

最终目标是建立一个数学模型，捕捉细胞增殖和细胞死亡信号通路之间的串扰。 本研究的重点是Ras/Raf和P13 K/Akt通路。 初步的数据将被收集，调查和说明这些途径之间的串扰。 随着理解的提高和数学描述的掌握，可以设想用于优化细胞培养或开发药物化合物的改进基础。