PECASE: Intracellular Signaling Networks in the Immune Response

PECASE：免疫反应中的细胞内信号网络

• 批准号: 0133594
• 负责人: Jason Haugh
• 金额: $ 37.5万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0133594&HistoricalAwards=false
• 关键词: PECASE; Intracellular; Signaling; Networks; Immune

Proposal Title: PECASE: Intracellular Signaling Networks in the Immune ResponseInstitution: North Carolina State UniversityThe objective of the proposed research is to study T lymphocyte (T cell) regulation at the intracellular level, with a focus on molecular signaling processes initiated by the cell surface receptors for the cytocines, interleukins (IL)-2 and (IL)-4. The specific objectives of this research include: (1) the quantitative analysis of pathway crosstalk interactions in IL-2 receptor signaling, using interventions that target specific intracellular molecules, (2) the characterization of the cooperation of IL-2 receptor-mediated signaling pathways in mediating T cell life (proliferation) and death (apoptosis) decision making, and (3) the elucidation of the synergistic effect of IL-2 and IL-4 on T cell expansion at the level of signaling network interactions. This research could provide new information to help modulate cell function, with potential application being the elucidation of therapeutic strategies.This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in May 2004.

提案标题：PECASE：免疫应答中的细胞内信号网络研究机构：北卡罗来纳州州立大学拟开展的研究的目的是在细胞内水平研究T淋巴细胞（T细胞）的调节，重点是细胞因子，白细胞介素（IL）-2和（IL）-4的细胞表面受体启动的分子信号传导过程。这项研究的具体目标包括：（1）使用靶向特定细胞内分子的干预，定量分析IL-2受体信号传导中的通路串扰相互作用，（2）表征IL-2受体介导的信号传导通路在介导T细胞生命中的协作（3）阐明IL-2和IL-4在信号网络相互作用水平上对T细胞扩增的协同作用。这项研究可以提供新的信息，以帮助调节细胞的功能，与潜在的应用是阐明的治疗策略。这个项目最初是作为一个职业奖资助，并转换为总统早期职业奖工程师和科学家（PECASE）奖在2004年5月。