"Direct Write" Techniques to Create Submicron, Arbitrary Protein Structures within Hyaluronan Hydrogels

在透明质酸水凝胶中创建亚微米、任意蛋白质结构的“直接写入”技术

• 批准号: 0829166
• 负责人: Christine Schmidt
• 金额: $ 49.57万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0829166&HistoricalAwards=false
• 关键词: Direct; Write; Techniques; Create; Submicron

CBET-0829166Christine Schmidt, University of Texas at AustinIntellectual merit The goal of this project is to develop novel techniques for controlling sub-cellular level biological cues in 3D. Other studies in this area have been unable to create such intricate architecture, at the submicron scale, and within 3D hydrogel systems. This project is truly unique and will provide an important platform for developing scaffolds for regenerative medicine and for more physiological, 3D in vitro culture systems. In addition, this research is particularly targeted for guiding axonal growth, which has potential implications for promoting regeneration in both the peripheral and central nervous systems.Broader impacts This interdisciplinary research is at the intersection of chemical and biomedical engineering, materials science, chemistry, optics/physics, and biology. Two graduate students and several undergraduate students will conduct the proposed research. The PI and Co-PI will work one-on-one with all students and each undergraduate student will also be paired with a graduate student mentor who will help guide research and oversee training. Furthermore, the PI and Co-PI's research groups are active in K-12 outreach programs (e.g., women and minority-based programs) as a means to educate young students about bioengineering, in addition to other scientific mentoring programs such as the Beckman Scholars Program and the Welch Summer Scholar Program.

CBET-0829166 Christine施密特，德克萨斯大学奥斯汀分校智力优点该项目的目标是开发用于控制3D亚细胞水平生物线索的新技术。该领域的其他研究无法在亚微米尺度和3D水凝胶系统内创建如此复杂的结构。该项目是真正独特的，将为再生医学和更生理的3D体外培养系统开发支架提供重要平台。 此外，该研究还特别针对指导轴突生长，这对促进外周和中枢神经系统的再生具有潜在意义。更广泛的影响这一跨学科研究是化学和生物医学工程、材料科学、化学、光学/物理学和生物学的交叉点。两名研究生和几名本科生将进行拟议的研究。PI和Co-PI将与所有学生一对一合作，每个本科生也将与研究生导师配对，他们将帮助指导研究和监督培训。此外，PI和Co-PI的研究小组积极参与K-12外展计划（例如，除了贝克曼学者计划和韦尔奇暑期学者计划等其他科学指导计划外，还设立了一个以妇女和少数民族为基础的计划），作为对年轻学生进行生物工程教育的一种手段。