Hydrogels and Oligonucleotide Hybridizaton for Sustained Delivery of Small Molecule Therapeutics
Hydrogels and Oligonucleotide Hybridizaton for Sustained Delivery of Small Molecule Therapeutics
批准号:
1159774
负责人:
Christine Schmidt
金额:
$47.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-08-01 至 2013-10-31
中文摘要
1159774/Schmidt该奖项由化学、生物工程、环境和运输系统部的生物技术、生物化学和生物质工程项目以及国家科学基金会材料研究部的生物材料项目共同资助。尽管做出了巨大的研究努力,但临床上还没有用于脊髓损伤后修复的疗法,部分原因是抑制性蛋白聚糖在限制中枢神经系统再生中起关键作用。因此,拟议项目的具体目标是开发治疗系统,以减少抑制性蛋白聚糖的负面影响,并随后增强轴突再生。为此,将开发针对蛋白酪氨酸磷酸酶(PTP)-σ(一种成年哺乳动物CNS中抑制性蛋白聚糖的受体)的新型适体拮抗剂。这项研究的另一个令人兴奋的组成部分涉及生物材料在动物体内持续递送生物分子的新用途。将通过使用寡核苷酸杂交的微粒/水凝胶复合物实现适体向受损脊髓的持续释放。该项目是真正的跨学科研究,在组织工程,核酸生物技术和神经科学的前沿。
英文摘要
1159774/ SchmidtThis award is funded jointly by the Biotechnology, Biochemical and Biomass Engineering Program in the Division of Chemical, Bioengineering, Environmental and Transport Systems and the Biomaterials Program in the Division of Materials Research at the National Science Foundation.Despite tremendous research efforts, there are no therapies in the clinic for repair after injury to the spinal cord, in part due to inhibitory proteoglycans that play a key role in limiting regeneration in the central nervous system. Thus, the specific goal of the proposed project is to develop therapeutic systems to decrease the negative effects of inhibitory proteoglycans and to subsequently enhance axon regeneration. To this end, novel aptamer antagonists against protein tyrosine phosphatase (PTP)-sigma, a receptor for inhibitory proteoglycans in the adult mammalian CNS, will be developed. Another exciting component of the proposed research involves a novel use of biomaterials for sustained delivery of biomolecules in animals. Sustained release of aptamers to the injured spinal cord will be achieved via microparticle/hydrogel composites using oligonucleotide hybridization. This project is truly interdisciplinary research at the forefront of tissue engineering, nucleic acid biotechnology and neuroscience.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Defining dynamic protein complexes in DNA repair by non-homologous end-joining
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批准号:MR/X008754/1
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项目类别:Research Grant
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资助金额:$61.49万
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财政年份:2023
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负责人:Christine Schmidt
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依托单位:
Ubiquitylation within and beyond the DNA damage response
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批准号:BB/N019997/1
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项目类别:Fellowship
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资助金额:$130.41万
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财政年份:2017
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负责人:Christine Schmidt
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依托单位:
Harnessing the Power of Apoptosis to Create Regenerative Acellular Biologic Scaffolds
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批准号:1605223
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项目类别:Standard Grant
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资助金额:$30.0万
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财政年份:2016
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负责人:Christine Schmidt
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依托单位:
Crystal Templated Polysaccharide Hydrogels
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批准号:1355712
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项目类别:Continuing Grant
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资助金额:$12.6万
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财政年份:2013
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负责人:Christine Schmidt
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依托单位:
Hydrogels and Oligonucleotide Hybridizaton for Sustained Delivery of Small Molecule Therapeutics
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批准号:1355713
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项目类别:Standard Grant
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资助金额:$41.07万
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财政年份:2013
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负责人:Christine Schmidt
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依托单位:
MRI-R2: Acquisition of High Resolution Environmental Scanning Electron Microscope (ESEM) for Characterization of Hydrogels, Nano-/Micro-Structures, & Cell-Material Interfaces
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批准号:0959037
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项目类别:Standard Grant
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资助金额:$54.43万
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财政年份:2010
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负责人:Christine Schmidt
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依托单位:
Conference: 2010 Biomedical Engineering Society Annual Fall Meeting: October 6-9, 2010, Austin, Texas
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批准号:1048884
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项目类别:Standard Grant
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资助金额:$1.7万
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财政年份:2010
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负责人:Christine Schmidt
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依托单位:
"Direct Write" Techniques to Create Submicron, Arbitrary Protein Structures within Hyaluronan Hydrogels
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批准号:0829166
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项目类别:Continuing Grant
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资助金额:$49.57万
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财政年份:2008
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负责人:Christine Schmidt
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依托单位:
Crystal Templated Polysaccharide Hydrogels
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批准号:0805298
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项目类别:Continuing Grant
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资助金额:$46.3万
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财政年份:2008
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负责人:Christine Schmidt
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依托单位:
Hyaluronan-based Materials and Size-dependent Mechanisms of Wound Healing
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批准号:0500969
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项目类别:Continuing Grant
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资助金额:$30.0万
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财政年份:2005
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负责人:Christine Schmidt
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依托单位:
NER: Directed Microelectronic Interfacing with Living Cells via Nanocrystal Quantum Dots
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批准号:0303442
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项目类别:Standard Grant
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资助金额:$10.0万
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财政年份:2003
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负责人:Christine Schmidt
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依托单位:
Angiogenic Hydrogel Biomaterials to Promote Nerve Regeneration
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批准号:0201744
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项目类别:Continuing Grant
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资助金额:$27.38万
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财政年份:2002
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负责人:Christine Schmidt
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依托单位:
CAREER: Understanding the Molecular Mechanics of Growth Cone Motility and Nerve Regeneration
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批准号:9733156
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项目类别:Continuing Grant
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资助金额:$20.0万
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财政年份:1998
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负责人:Christine Schmidt
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依托单位:
Novel Biodegradable Electrically Conducting Polymers for Nerve Regeneration
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批准号:9702882
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项目类别:Standard Grant
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资助金额:$1.8万
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财政年份:1997
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负责人:Christine Schmidt
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依托单位:
国内基金
海外基金
靶向 TTR 的新型 Oligonucleotide-GalNAc 偶联物的高效构建与设计
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批准号:
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项目类别:省市级项目
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资助金额:--
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批准年份:2025
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负责人:聂辉军
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依托单位:
oligonucleotide探针及弗氏菌根际生态的研究
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批准号:39170048
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项目类别:面上项目
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资助金额:3.8万元
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批准年份:1991
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负责人:张忠泽
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依托单位: